The Largest Single Health Damaging Event in American History
and where were our ‘skeptics’ for the last 24 years while this occurred? Chasing ghosts, Bigfoot and UFO hunters…
It has always been more than simply interesting that our 1995-genesis epidemics of gluten sensitivity and IBS just mysteriously happened to coincide with our introduction of glyphosate into 95+% of the wheat, corn, soy and canola food supply. But if that were the only two flash-skyrocketing maladies the American public has suffered since 1995 then my curiosity might not have been piqued. And let’s be clear, Americans are the heaviest consumers of glyphosate, and are for the most part, the ones suffering most from these new top 10 prescribed-for epidemic maladies. Parsimony under an ethical governance of science, would dictate plurality due to observation, relationship and risk, under the scientific method. However, it has taken the sickening of our entire nation to alert us to this horrendous act.
Why? Because of corrupt oligarch influence and fake skepticism, plain and simple. The act of blocking or not skeptically researching the impact of glyphosate on our collective intestinal health since 1995 – is unconscionable pseudoscience. This should be pursued by a class action lawsuit – god knows that my family has suffered enough from this malfeasance and incompetence. Your claims that we are anti-science be damned. On the contrary, science is stepping back in and taking control back from this case study in corruption.
There are six compelling reasons why the science performed to date on Glyphosate is woefully insufficient, and re-disposition by the EPA, through complete science performed by neutral third parties regarding Glyphosate and its enabling GMO seed monopoly, should be once again evaluated. The scientific method does not dictate that preliminary conclusions, once published, can never again be examined just because SSkeptics declare otherwise. In fact, Ethical Skepticism demands that we re-examine the role of this harmful technology in American diets and in overall human and ecological health.
Glyphosate
/ N-(phosphonomethyl) glycine / : Herbicide, assigned EPA Human Toxicity Category III and WHO Toxicity Group 2A ‘probably carcinogenic to humans.’ Toxicity enabled to varying levels in different species, by acting as a water soluble analog of the protein glycine, which deleteriously interferes with the synthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan; effectively killing bacteria and plants which depend upon the EPSP Synthase pathway. A dependency based technology utilized by Monsanto to establish a strategically planned seed sourcing monopoly. This an outcome of Glyphosate’s complimentary relationship with patented GMO seed modifications, enforced for use throughout a compliant ABCD Seed Cartel,‡ regarding Glyphosate tolerance.
Glyphosate Use Originally Approved/Mandated Under Outdated and Incomplete Science. Which now shows alarming real world test data, to wit:
Environmental Health201615:19 DOI: 10.1186/s12940-016-0117-0 © Myers et al. 2016 Received: 8 June 2015, Accepted: 6 February 2016, Published: 17 February 2016
We conclude that: (1) GBHs are the most heavily applied herbicide in the world and usage continues to rise; (2) Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions; (3) The half-life of glyphosate in water and soil is longer than previously recognized; (4) Glyphosate and its metabolites are widely present in the global soybean supply; (5) Human exposures to GBHs are rising; (6) Glyphosate is now authoritatively classified as a probable human carcinogen; (7) Regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science.
Genetically engineered crops, glyphosate and the deterioration of health in the United States of America
Journal of Organic Systems, 9(2), 2014; ISSN 1177-4258
Abstract
A huge increase in the incidence and prevalence of chronic diseases has been reported in the United States (US) over the last 20 years. Similar increases have been seen globally. The herbicide glyphosate was introduced in 1974 and its use is accelerating with the advent of herbicide-tolerant genetically engineered (GE) crops. Evidence is mounting that glyphosate interferes with many metabolic processes in plants and animals and glyphosate residues have been detected in both. Glyphosate disrupts the endocrine system and the balance of gut bacteria, it damages DNA and is a driver of mutations that lead to cancer. In the present study, US government databases were searched for GE crop data, glyphosate application data and disease epidemiological data. Correlation analyses were then performed on a total of 22 diseases in these time-series data sets.
The Pearson correlation coefficients are highly significant (< 10-5) between glyphosate applications and hypertension (R = 0.923), stroke (R = 0.925), diabetes prevalence (R=0.971), diabetes incidence (R= 0.935), obesity (R = 0.962), lipoprotein metabolism disorder (R = 0.973), Alzheimer’s (R = 0.917), senile dementia (R = 0.994), Parkinson’s (R=0.875), multiple sclerosis (R=0.828), autism (R= 0.989), inflammatory bowel disease (R = 0.938), intestinal infections (R = 0.974), end stage renal disease (R = 0.975), acute kidney failure (R=0.978), cancers of the thyroid (R = 0.988), liver (R = 0.960), bladder (R = 0.981), pancreas (R = 0.918), kidney (R = 0.973) and myeloid leukaemia (R = 0.878).
The Pearson correlation coefficients are highly significant (< 10-4) between the percentage of GE corn and soy planted in the US and hypertension (R = 0.961), stroke (R = 0.983), diabetes prevalence (R =0.983), diabetes incidence (R = 0.955), obesity (R= 0.962), lipoprotein metabolism disorder (R =0.955), Alzheimer’s (R = 0.937), Parkinson’s (R = 0.952), multiple sclerosis (R = 0.876), hepatitis C (R= 0.946), end stage renal disease (R = 0.958), acute kidney failure (R = 0.967), cancers of the thyroid (R = 0.938), liver (R = 0.911), bladder (R = 0.945), pancreas (R = 0.841), kidney (R = 0.940) and myeloid leukaemia (R = 0.889). The significance and strength of the correlations show that the effects of glyphosate and GE crops on human health should be further investigated.
Shehata AA1, Schrödl W, Aldin AA, Hafez HM, Krüger M.; Curr Microbiol. 2013 Apr;66(4):350-8. doi: 10.1007/s00284-012-0277-2. Epub 2012 Dec 9.
Abstract
The use of glyphosate modifies the environment which stresses the living microorganisms. The aim of the present study was to determine the real impact of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. The presented results evidence that the highly pathogenic bacteria as Salmonella Entritidis, Salmonella Gallinarum, Salmonella Typhimurium, Clostridium perfringens and Clostridium botulinum are highly resistant to glyphosate. However, most of beneficial bacteria as Enterococcus faecalis, Enterococcus faecium, Bacillus badius, Bifidobacterium adolescentis and Lactobacillus spp. were found to be moderate to highly susceptible. Also Campylobacter spp. were found to be susceptible to glyphosate. A reduction of beneficial bacteria in the gastrointestinal tract microbiota by ingestion of glyphosate could disturb the normal gut bacterial community. Also, the toxicity of glyphosate to the most prevalent Enterococcus spp. could be a significant predisposing factor that is associated with the increase in C. botulinum-mediated diseases by suppressing the antagonistic effect of these bacteria on clostridia.
Glyphosate interferes with :
Intestinal Dendritic Cell EPSP Synthase, effectively killing those critical immune system messenger cells as part of glyphosate’s well established EPSPS microbicide effectiveness. This renders the gut/immune system unable to communicate microbial tolerance to the innate and adaptive immune systems; effectively triggering celiac disease-like symptoms in humans, including nausea, diarrhea, skin disorders, macrocytic anemia, b-vitamin depletion, depression, IBS, IBD, rosacea and several other longer term chronic illnesses.
Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology. 2013;6(4):159-184. doi:10.2478/intox-2013-0026.
Phenylalanine – Elevates the mood, ensures good function of the autonomous and central nervous system (breathing, sleeping, calmness), essential for memory and learning and regulates the appetite by causing excess hunger until this minor protein is fulfilled. Otherwise one short of phenylalanine will overeat in order to attain minor proteins needed.
Tyrosine – It is a building block for several important neurotransmitters, including epinephrine, norepinephrine, serotonin, and dopamine. Neurotransmitters help nerve cells communicate and influence mood. Tyrosine also helps produce melanin (the pigment responsible for hair and skin color) and helps in the function of organs responsible for making and regulating hormones, including the adrenal, thyroid, and pituitary glands.
Tryptophan – The body uses tryptophan to help in the uptake of niacin (Vitamin B3 – lower cholesterol and triglycerides (types of fat) in the blood) and serotonin. Serotonin is thought to produce healthy sleep and a stable mood.
Glycine – Essential for a healthy, normally functioning digestive system. It helps regulate the synthesis of the bile acid used to digest fats. Helps establish the mucosa barrier which blocks toxins from crossing the intestinal boundary – reduces the amount of auto-immune triggers in the blood.
Disruption of Kidney and Liver mRNA splicing and small nucleolar RNA – were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption.
Disruption of Genes Controlling Chromatin Structure – Genes (especially histone-lysine N-methyltransferases) were mostly upregulated in Kidney and Liver measures.
Disruption of Genes Related to Respiratory Chain Complex I and the Tricarboxylic Acid Cycle – Pathway analysis suggests a modulation of the mTOR and phosphatidylinositol signalling pathways. Gene disturbances associated with the chronic administration of ultra-low dose Roundup reflect a liver and kidney lipotoxic condition and increased cellular growth that may be linked with regeneration in response to toxic effects causing damage to tissues.
Collectively – the interference with these proteins, DNA functions and elimination of vital gut flora causes in humans:
- Loss of well being and up mood – creates anxiety
- Endocrine function loss (Hypo-thyroid, Hypo-pituitary, Adrenal-Thyroid-Pituitary Axis)
- Digestive screening loss and Auto-Immune flareups
- Loss of protein synthesis in muscles
- Loss of B vitamin uptake – especially in low-methylation genetic profile individuals
- Higher triglycerides and cholesterol, liver stress
- Chronic inflammatory diseases
- Chronic digestive tract diseases
- Liver pathology and morphology changes
- Kidney pathology and morphology changes
- Dysbiosis
- IBS/IrBD
- Disruption of cell’s ability to break down and burn sugars (diabetes)
Where were the SSkeptics when this was all approved inside 3 years? Busy ranting about supplements, ghosts, UFO’s, the Loch Ness Monster, alternative medicine and ulcers being caused by coffee and stress.
1. The studies upon which EPA Approval was granted are based on preliminary and aged experimental observation.
EPA Initial Approval
1991 RED Facts: Glyphosate; EPA-738-F-93-011; U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 1993.
2. The EPA Approval was granted on only one scant 1970 / 80’s study series, conducted on animals (rats, rabbits, beagles); wherein the objectivity is in question, of both the EPA and Monsanto in assessing the regulatory applicability of these early studies, as they were all completed only by Monsanto.
Approval Basis: All Monsanto Studies
Reregistration Eligibility Decision (RED) Glyphosate; EPA-738-F-93-011; U. S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 1993. Referenced studies (Increase in autism study on right from Nevison, Environmental Health; 2014, 13:73 Page 4 of 16 : http://www.ehjournal.net/content/13/1/73).
1985 Reyna, M. Twelve month study of glyphosate administered by gelatin capsule to beagle dogs. Unpublished Report no. 830116, project no. ML-83-137, 1985, submitted to U.S. Environmental Protection Agency by Monsanto Company Environmental Health.
1983 Knezevich, A.; Hogan, G. A chronic feeding study of glyphosate (Roundup technical) in mice. Unpublished Report no. BDN-77420, project no. 77-2061, 1983, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by BioDynamics, Inc.
1970 Birch, M. Toxicological investigation of CP 67573-3. Unpublished Report no. 4-70-90, 1970, submitted to U.S. Environmental Protection Agency by Monsanto Corporation, prepared by Younger Laboratories, Inc.
1988 Blaszcak, D., Primary dermal irritation study in rabbits for glyphosate technical (wetcake). Unpublished Report no. BD-88- 114, project number 4887, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Corporation, prepared by BioDynamics, Inc.
1980 Rodwell, D. E.; Tasker, E. J.; Blair, A. M.; et al. Teratology study in rats. Unpublished report no. 401-054, unpublished study no. 999- 021, 1980, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by International Research and Development Corporation.
1980 Rodwell, D. E.; Tasker, E. J.; Blair, A. M.; et al. Teratology study in rats. Unpublished report no. 401-056, 1980, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by International Research and Development Corporation.
1988 Monsanto Corporation. The metabolism of glyphosate in Sprague Dawley rats- Part I. Excretion and tissue distribution of glyphosate and its metabolites following intravenous and oral administration. Unpublished report no. MSL-7215, 1988, submitted to WHO by Monsanto Ltd, prepared by Monsanto Environmental Health Laboratory.
1988 Ridley, W.; Mirly, K. The metabolism of glyphosate in Sprague-Dawley rats. Part I. Excretion and tissue distribution of glyphosate and its metabolites following intravenous and oral administration. Unpublished report no. 86139 (MSL 7215), RD no. 877, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Company.
1988 Howe, R.; Chott, R.; McClanahan, R. Metabolism of glyphosate in Sprague-Dawley rats. Part II: Identification, characterization, and quantitation of glyphosate and its metabolites after intravenous and oral administration. Unpublished report no. MSL-7206, RD No. 877, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Company.
1978 Brightwell, B.; Malik, J. Solubility, volatility, absorption, and partition coefficients, leaching and aquatic metabolism of MON 0573 and MON 0101. Unpublished report no. MSL-0207, 1978, submitted to U.S. Environmental Protection Agency by Monsanto Company.
1990 McMullan, P.; Honeggar, J.; Logusch, E. Confined rotational crop study of glyphosate Part II. Quantitation, characterization and identification of glyphosate and its metabolites in rotational crops. Unpublished report no. MSL-981, 1990, submitted to U.S. Environmental Protection Agency by Monsanto Agricultural Labs.
1978 Fink, R.; Beavers, J. One-generation reproduction study in bobwhite quail: glyphosate technical. Unbpublished report no. 139- 141. 1978, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Wildlife International Ltd.
1982 McAllister, W.; McKee, M.; Schofield, M.; et al. Chronic toxicity of glyphosate (AB-82-036) to Daphnia magna under flow-through test conditions. Chronic toxicity final report ABC 28742. Unpublished report, 1982, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Analytical Bio-Chemistry Laboratories, Inc.
1974 Bentley, R., Acute toxicity of roundup (technical) to grass shrimp (Palaemonetas vulgaris) and fiddler crab (Uca pagilator). Unpublished report no. SF1536, 1974, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Bionomics, Inc.
1972 Frasier, W. D.; Jenkins, G. The acute contact and oral toxicities of CP67573 and MON2139 to worker honey bees. Unpublished report no. 4G1444, 1972, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Huntingdon Research.
In the instances of the third party labs which completed studies, subsequently routed through Monsanto to the EPA, a glance at LinkedIn and Moody’s shows that several of these companies were staffed by ex Monsanto and Syngenta employees, all in the St. Louis and Columbia, Missouri local area, or were small or one man or short lived businesses, operating around the period of the study. Nor did these firms continue their research after the EPA approval. A curious set of actions given that now human and higher order mammal and prodigious field data are available, which could improve their confidence interval risk profiles to an impeccable level of integrity. Yet they just ceased study altogether. This brings their third party objectivity, and their role as scientists, into essential question.
3. The sample sizes of observational data for all coincident maladies is much more easily accessible/collectible today. As well, Monsanto coordinated the release of studies, patents and EPA approvals as part of a liability risk mitigation strategy regarding these maladies, along with its connected seed sourcing monopoly business strategy
As you can see from the above graphic, the amount of human data available with which to truly assess the safety of Glyphosate, is on the order of 30,000 times as large as it was in the 1986 – 1991 timeframe in which the Approval studies were conducted. In addition, the littany of condemning, or alarm raising studies continues to proliferate AFTER the Approval in 1991 by the EPA. See the listing below.
What Monsanto has accomplished here is brilliant strategy. They planned the timed arrival of the Glyphosate Resistant Genome Abstracts onto the market commensurate with the expiration of their Glyphosate patents. This allowed their domain of Glyphosate to be liability umbrella covered by the former EPA guidance on the herbicide/toxicant/biocide, while the open domain market use of Glyphosate now will be administered under the newer understandings of toxicity which have been discovered since Approval by the EPA. In this way, Monsanto dodges the liability on the negative health effects of Glyphosate, endures the ramp up period for the growth of business from a gateway patent, and secures ultimate risk-free profitability through a complimentary and solely dependent technology: Glyphosate resistance through patented GM seed.
A brilliantly executed strategy.
Toxicology Studies Executed AFTER FDA Approval and Glyphosate Enabling GMO Maps were Abstracted by Monsanto
Please note that after the EPA approval in 1991, despite the prodigious amount of new contra indicative data since on HUMANS and higher order mammals, Monsanto ceased critical safety-oriented clinical studies of Glyphosate altogether. They left it to the rest of the world to perform lifecycle and safety-diligence science through a nascent sufficient level of observational and intelligence base of data. Knowing that these opponents would have a ‘King of the Hill’ battle against bureaucracy, collusion, corruption and false skeptics, Monsanto strategically planned to sit back and do nothing thereafter. Notice that not even one study since, has been completed by Monsanto or their shill third party labs which underpinned the 1991 EPA approval effort.
2015 Journal of Environmental Health, Environmental Health Aug 25 2015, 14:70 doi:10.1186/s12940-015-0056-1 – Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure.
2014 Journal of Seed Science, Print version ISSN 2317-1537; J. Seed Sci. vol.36 no.1 Londrina 2014 http://dx.doi.org/10.1590/S2317-15372014000100008 Yield and quality of wheat seeds as a function of desiccation stages and herbicides.
2006 Tomlin, C. D. S. The Pesticide Manual: A World Compendium, 14th ed.; British Crop Protection Council: Hampshire, UK, 2006; pp 545- 548.
1998 Roberts, T. R. Metabolic Pathways of Agrochemicals-Part 1: Herbicides and Plant Growth Regulators; The Royal Society of Chemistry: Cambridge, UK, 1998; pp 396-399.
2002 Herbicide Handbook, 8th ed.; Vencill, W. K. Ed.; Weed Science Society of America: Lawrence, KS, 2002; p 231-234.
2000 Giesey, J. P.; Dobson, S.; Solomon, K. R. Ecotoxicological risk assessment for Roundup herbicide. Rev. Environ. Contam. Toxicol. 2000, 167, 35-120.
2010 SRC PhysProp Database: Glyphosate; Syracuse Research Corporation. http://www.syrres.com/what-we-do/databaseforms.aspx?id=386 (accessed Dec 2007), updated Jan 2010.
2000 Shaner, D. L. The impact of glyphosate-tolerant crops on the use of other herbicides and on resistance management. Pest Manag. Sci. 2000, 56, 320-326.
1991 Franz, J. E.; Mao, M. K.; Sikorski, J. A. Glyphosate: A Unique Global Herbicide; American Chemical Society: Washington, DC, 1997; pp 521-527, 604-605, 615.
1996 WHO. Data Sheets on Pesticides: Glyphosate; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Geneva, Switzerland, 1996.
2006 Wu, J. Y.; Chang, S. S.; Tseng, C. P.; Deng, J. F.; Lee, C. C. Parenteral glyphosate-surfactant herbicide intoxication. Am. J. Emerg. Med. 2006, 24 (4), 504-506.
2000 Williams, G. M.; Kroes, R.; Munro, I. C. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 2000, 31, 117-165.
2004 Bradberry, S. M.; Proudfoot, A. T.; Vale, J. A. Glyphosate poisoning. Toxicol. Rev. 2004, 23 (3), 159-167.
2000 Bates, N.; Campbell, A. Handbook of Poisoning in Dogs and Cats – Glyphosate; Campbell, A.; Chapman, M., Eds.; Blackwell Science Ltd: Oxford, England, 2000; pp 135-138.
1998 Monsanto Department of Medical and Health Sciences. Roundup and other gyphosate/tallowamine surfactant-containing herbicides: The clinical effects and their managment. Unpublished report, 1994, cited in Burgat, V.; Keck, G.; Guerre, P.; Bigorre, V.; Pineau, X. Glyphosate toxicosis in domestic animals: A survey from the data of the Centre National d’Informations Toxicologiques Veterinaires (CNITV). Vet. Hum.Toxicol. 1998, 40 (6), 363-367.
2004 Rattray, N. J. Glyphosate acid: 4-hour acute inhalation toxicity study in rats. Unpublished Report no. CTL/P/4882, study no. HR2884, 1996, submitted to WHO by Syngenta Crop Protection AG, Basel, Switzerland, prepared by Zeneca Agrochemicals, Central Toxicology Laboratory, Alderley Park, Maccelsfield, Cheshire, England. Pesticide Residues in Food – 2004: Toxicological evaluations; International Programme on Chemical Safety, World Health Organization: Geneva, Switzerland, 1996.
2004 Welch, S. Glyphosate. Clinical Veterinary Toxicology; Plumlee, K. H., Ed.; Mosby: St. Louis, 2004; pp 162-163.
1998 Burgat, V.; Keck, G.; Guerre, P.; Bigorre, V.; Pineau, X. Glyphosate toxicosis in domestic animals: A survey from the data of the Centre National d’Informations Toxicologiques Veterinaires (CNITV). Vet. Hum. Toxicol. 1998, 40 (6), 363-367.
1999 Acquavella, J. F.; Weber, J. A.; Cullen, M. R.; Cruz, O. A.; Martens, M. A.; Holden, L. R.; Riordan, S.; Thompson, M.; Farmer, D. Human ocular effects from self-reported exposures to Roundup herbicides. Hum. Exp. Toxicol. 1999, 18 (8), 479-486.
2009 Glyphosate. Human-Health Assessment Scoping Document in Support of Registration Review; U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 2009.
2004 Acquavella, J. F.; Alexander, B. H.; Mandel, J. S.; Gustin, C.; Baker, B.; Chapman, P.; Bleeke, M. Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study. Environ. Health Perspect. 2004, 112 (3), 321-326.
2007 Cavas, T.; Konen, S. Detection of cytogenic and DNA damage in peripheral erythrocytes of goldfish (Carassius auratus) exposed to a glyphosate formulation using the micronucleus test and the comet assay. Mutagenesis 2007, 22 (4), 263-268.
2004 FAO. Pesticide Residues in Food – Evaluations Part 2: Toxicological; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Rome, Italy, 2004.
2005 De Roos, A. J.; Blair, A.; Rusiecki, J. A.; Hoppin, J. A.; Svec, M.; Dosemeci, M.; Sandler, D. P.; Alavanja, M. C. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ. Health Perspect. 2005, 113 (1), 49-54.
2004 Moxon, M. E. Glophosate acid: multigeneration reproduction toxicity in rats. Unpublished report no. CTL/P/6332, study no. RR0784, 2000, submitted to WHO by Syngenta Crop Protection AG, Basel, Switzerland, prepared by Zeneca Agrochemicals, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, England. Pesticide Residues in Food – Evaluations Part 2: Toxicological; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Rome, Italy, 2004.
2003 Hori, Y.; Fujisawa, M.; Shimada, K.; Hirose, Y. Determination of the herbicide glyphosate and its metabolite in biological specimens by gas chromatography-mass spectrometry. A case of poisoning by roundup herbicide. J. Anal. Toxicol. 2003, 27 (3), 162-166.
2002 Aprea, C.; Colosio, C.; Mammone, T.; Minoia, C.; Maroni, M. Biological monitoring of pesticide exposure: a review of analytical methods. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 769 (2), 191-219.
2008 Motojyuku, M.; Saito, T.; Akieda, K.; Otsuka, H.; Yamamoto, I.; Inokuchi, S. Determination of glyphosate, glyphosate metabolites, and glufosinate in human serum by gas chromatography-mass spectometry. J. Chromatogr. B 2008, 875, 509-514.
2004 Biagini, R. E.; Smith, J. P.; Sammons, D. L.; MacKenzie, B. A.; Striley, C. A.; Robertson, S. K.; Snawder, J. E. Development of a sensitivity enhanced multiplexed fluorescence covalent microbead immunosorbent assay (FCMIA) for the measurement of glyphosate, atrazine and metolachlor mercapturate in water and urine. Anal. Bioanal. Chem. 2004, 379 (3), 368-374.
2007 Curwin, B. D.; Hein, M. J.; Sanderson, W. T.; Striley, C.; Heederik, D.; Kromhout, H.; Reynolds, S. J.; Alavanja, M. C. Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in iowa. Ann. Occup. Hyg. 2007, 51 (1), 53-65.
2008 Tsui, M. T. 60. K.; Chu, L. M. Environmental fate and non-target impact of glyphosate-based herbicide (Roundup) in a subtropical wetland. Chemosphere 2008, 71, 439-446.
2005 Curwin, B. D.; Hein, M. J.; Sanderson, W. T.; Nishioka, M. G.; Reynolds, S. J.; Ward, E. M.; Alavanja, M. C. Pesticide contamination inside farm and nonfarm homes. J. Occup. Environ. Hyg. 2005, 2 (7), 357-67.
2004 Howe, C. M.; Berrill, M.; Pauli, B. D.; Helbing, C. C.; Werry, K.; Veldhoen, N., Toxicity of glyphosate-based pesticides to four North American frog species. Environ. Toxicol. Chem. 2004, 23 (8), 1928-1938.
4. There exists a pronounced rise in diseases associated with the original toxicity issues evaluated in the EPA Approval; specifically pancreatic, endocrine and skin inflammation disorders
OCKHAM’S RAZOR PLURALITY HAS BEEN DRAMATICALLY SURPASSED: There Exists a Problem with Our Food – And No, Exercising More Will Not Fix This
Compare the chart at the right with the Glyphosate employment curve shown above; and remember that by 2008, Glyphosate tolerant crops constitute 85 – 90% of the food bio-availability in their respective use classes. I am not sure that we can wait to finally find out what it is we must to do to convince the oppressive Social Skepticism movement to step aside and allow real actual science to proceed. To continue to actively ignore this set of maladies, endocrine, inflammation and auto-immune in nature, is the height of malicious incompetence. And remember, one principal goal of the Social Skepticism cabal is the Cultivation of Ignorance, the false premise that you must bring final and conclusive proof at the beginning of the scientific method; along with the commensurate manipulation of the conscience of science to support oligarch cronies. This constituting just one technique inside the variety of ways to cultivate ignorance through manipulation of the scientific method. The graphic to the right is posted, courtesy of Farm Wars (http://farmwars.info/?p=11543) and demonstrates the dramatic growth in diabetes incident upon the US population underway. No, this is not simply because the population is aging. Our children are inheriting these diseases on a regular basis now. To presume that you know the impetus behind this alarming statistic, as a means to squelch study, not stimulate it – is pseudoscience. The advocate producing this comparative on the right, indexing the coincidence between GM Food technologies and the rate of increase in diabetes, is petitioning for research – not providing excuse to block research – so he or she is actually conducting work in accordance with the scientific method.
But the bad news is that diabetes apparently is a 2 year lag sensitive malady induced from environmental factors, apparently factors which appeared in the American diet around 1995. But cancer on the other hand is more of a 15 to 40 year lag statistic as we have seen from smoking data and its impacts on stomach, bladder, esophageal and lung cancer data. Accordingly we should see a curve building now, stemming from the 1995 introduction of the first broad scale glyphosate resistant crops in 1995. Indeed, when we examine pancreatic cancer, we see exactly what might be expected; in fact, a terrifying picture.
Not only are we experiencing a pandemic rate of diabetes, but pancreatic cancer, once rare, has now skyrocketed to become the fourth leading cause of cancer death in the United States. The United States not only leads the world in rates of diabetes, but in rates and deaths of pancreatic cancer as well. We cannot continue to blame these observations on super sized meals, in absence of having really conducted any research. A counter claim cannot be tendered in a pluralistic argument, without evidence. According to the National Cancer Institute, in 2014, over 46,400 people will be diagnosed with pancreatic cancer – this is up 114% since the 2012 GLOBOCAN North American measured rate, which was already 18% higher than the rest of the planet on average. ¹ ³
US Pancreatic Cancer Case Incidence 2014 46,400 N American Avg Pancreatic Cancer Incidence 2.6% World Avg Pancreatic Cancer Incidence 2.2%
And no, arch cynic Steven Novella cannot blame these stats on ‘an increase in focus on and diagnosis of’ since 80+% of these victims die of this cancer and usually in about a little over a year on average. A study leader Dr. Peter Storz, a cancer biologist at the Mayo Clinic in Jacksonville, FL, who – with colleagues – describes their findings in the journal Cancer Discovery, says: ²
Our study shows a “direct link between Kras mutations and the inflammatory environment that drive the initiation of pancreatic cancer.”
It is clear from the post 1991 evidence and studies cited in section 3 above, that pancreatic inflammatory impacts were a principal observed element inside the observed set of effects of glyphosate on higher order mammals. The criminal stupidity displayed on the part of our arch SSkeptics, seeks to BLOCK, yes BLOCK the science which could prove matters such as the impact of this food additive, glyphosate, on our public health.
5. Glyphosate is not optional. You can’t wash Glyphosate off, and it is contained in 90% of the bio-available foods of each major US Consumer Food category.
One cannot avoid Glyphosate except through an enormous amount of diligent research and through a highly restrictive diet. The products do not inform their victims of the incumbent potential dangers documented since 1991. Rosacea, Obesity from Endocrine Collapse and the requisite Auto-Immune Disruption, are all a concern among Americans today. I was able to alleviate these symptoms by elimination of Glyphosate related foods. Elimination of corn, wheat, soy, canola dairy and alfalfa is not an accomplishment which the vast majority of Americans can achieve. The foods are not labelled such that they can, even if they wanted. Resource sites provided by the American Autoimmune Related Diseases Association, for persons truly interested In or suffering from Endocrine, Rheumatoid or Autoimmune Diseases:
http://www.aarda.org/Basic_Autoimmunity.swf
http://www.aarda.org/Rheumatic_Autoimmune_Disease.swf
Related original studies which cited that pancreatic, endocrine, skin and inflammation disorders were an issue
Arbuckle, T. E.; Lin, Z.; Mery, L. S. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environ. Health Perspect. 2001, 109 (8), 851-7.
Maibach, H. I. Irritation, sensitization, photoirritation and photosensitization assays with a glyphosate herbicide. Contact Derm. 1986, 15, 152-156.
Talbot, A. R.; Shiaw, M. H.; Huang, J. S.; Yang, S. F.; Goo, T. S.; Wang, S. H.; Chen, C. L.; Sanford, T. R. Acute poisoning with a glyphosatesurfactant herbicide (‘Roundup’): A review of 93 cases. Hum. Exp. Toxicol. 1991, 10 (1), 1-8.
McConnel, R. A chronic feeding study of glyphosate (Roundup technical) in mice: pathology report on additional kidney sections. Unpublished project no. 77-2061A, 1985.
Stout, L.; Ruecker, F. Chronic study of glyphosate administered in feed to albino rats. Unpublished Report no. MSL-10495 R.D. 1014, 1990.
Lavy, T. L. Conifer seedling nursery worker exposure to glyphosate. Arch. Environ. Contam. Toxicol. 1992, 22, 6-13.
Jauhiainen, A.; Rasanen, K.; Sarantila, R.; Nuutinen, J.; Kangas, J. Occupational exposure of forest workers to glyphosate during brush saw spraying work. Am. Ind. Hyg. Assoc. J. 1991, 52 (2), 61-64.
Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology. 2013;6(4):159-184. doi:10.2478/intox-2013-0026.
6. The Public is asking that the science be completed/updated. They would like to be informed so they can make choices. This is their right.
Significant portions of the scientifically and medically minded, as well as the professional population of our country are standing up and raising concerns over what they are observing in their children. No, the rise in obesity, diabetes, thyroid disease and other maladies cannot be explained by calories and exercise. No, you cannot dissuade ethical questions by charades of ‘critical’ or ‘skeptical’ thinking.
“Nearly one quarter, 25 percent of all Americans ages 17-24 are too overweight to serve. Obesity is not only affecting those who can qualify for military service, it is also creating challenges for our active duty military,” Tomaszeski said.
– U.S. Navy Rear Admiral Steven Tomaszeski, CBS Baltimore, ‘Obesity Affects Number Of Those Eligible For Military Service;’ Nov 20, 2014.
Yes, there is a growing fire. The fire is the observed inflammation in our bodies, skyrocketing since 1995, along with the incumbent increase in Endocrine-Immune Disruption. Rome is burning. It is our national health, security and prosperity. All placed in danger while we fiddle with a
- 1.2% increase in the crop price (6 cents a bushel net on sale),
- 7.5% increase in yield and
- savings of 2 cents a bushel on cost of production.†
As many others have expressed, let me offer up a resounding ‘yawn’ to this level of productivity and yield gain. Post harvest perishment rates, especially in famine stricken areas of the globe are well in excess of 40%. I work supporting nine of these nations, and trust me, yield is not the issue they face. Post harvest perishment is where the danger of famine resides, not in theoretical hectare ‘yields.’
I attended a symphony with an oncologist and her husband recently and the subject of autoimmune disease and diet came up. She was a cancer survivor herself at age 29! This is what she related to me:
“I could never say this on the record in my profession, but the incident of previously rare cancers no longer being that rare, along with a rise in the ‘old age’ associated cancers occurring in those my age, is dramatic. Whatever it is has occurred in the last 12 years because the stats are skyrocketing. It is obviously something environmental, but further, I think it is diet related.”
~ 29 Year Old Breast Cancer Survivor and Oncologist
The Michael Shermer’s of the world think that your suffering, your food sensitivities, your intestinal dysfunction, facial sores, cancers, anxiety, IBS, and endocrine maladies – ARE ALL A FICTIONAL COMEDY – they mock you in your suffering.
We cannot continue to sacrifice our bodies for this fairy tale of how famine works – along with Social Skeptic cluelessness and arrogance concerning the suffering of everyday people. This yield and productivity result is solely intended to be employed in predatory market dynamics, masquerading as a dilettante understanding of famine mercy. Parallel to much of American economics, we are using predatory pricing, efficiencies and sourcing cartels (seed sourcing in this case, emulating China) in order to put small and medium sized competitors out of business, to the benefit of social oligopolies. These tactics are NOT mechanisms of capital economies, rather socialist economies. The measurable rise of royalty and elite elicits indication as to what is occurring in our agri-foods industry. Socialism always bears a royalty class, hidden or visible.
Now it is up to activists like me, who were able to improve their health and reverse these diseases by eliminating specific foods (wheat, dairy, corn, canola oil, soy, cottonseed oil, alfalfa), who must petition scientists we work with and know, to start considering the idea that we must begin to conduct science on the safety and health impacts of the food we are consuming. Believe it or not, science that has been obstructed by the very organization who’s job it should have been to protect us in the first place.
Plurality has been established on this issue: Our food is in question – Glyphosate is in question – We must begin the actual third party, skeptical science.
¹ GLOBOCAN Worldwide Estimated Cancer Incidence 2012, sorted by cancer site; North America/United States/Pancreatic Cancer; http://globocan.iarc.fr/Pages/fact_sheets_population.aspx
² Researchers identify first molecular steps that lead to pancreatic cancer; Last updated: 10 November 2014 at 3am PST; Medical News Today, http://www.medicalnewstoday.com/articles/285173.php?linkId=10916036
³ National Cancer Institute, Pancreatic Cancer Summary; http://www.cancer.gov/cancertopics/types/pancreatic
† Hybrid Wheat, Cisar/Cooper, FAO Document Repository, http://www.fao.org/docrep/006/Y4011E/y4011e0c.htm
‡ ABCD Seed Cartel: Archer Daniels Midland Company, Bunge, Cargill , Louis Dreyfus Group.
“You’ve got a very high TSH and low free T3. I suspect you may have hypothyroidism.” So says the doctor, at my son’s collegiate junior year annual checkup. His flatmate was just diagnosed with diabetes at age 21 and has had rheumatoid arthritis since age 15. My son should feel fortunate, because hypothyroidism is the least horrid of the modern array of epidemic autoimmune disorders which now plague American society. Yes I say American society, because I have conducted medical strategies for several nations, gathering and processing enormous amounts of health data, and observing their populations’ health and diet habits first hand. Their populations do not exhibit these endemic rates of autoimmune disorder we have in the United States (although if they are shipped American foods in any significant scale, this principle is no longer correct). But what do I know? In Social Skepticism you learn quickly that in order to do real science, you must avoid asking tough questions, stay away from first hand observations, and stay out of the field. There is no data which cannot be overcome by a clever one-liner or circular recitation.
“With the rapid increase in autoimmune diseases, it clearly suggests that environmental factors are at play due to the significant increase in these diseases. Genes do not change in such a short period of time,” says Virginia T. Ladd, President and Executive Director of the American Autoimmune Related Diseases Association (AARDA). She goes on to label the current state of autoimmune disease an epidemic that should be of great concern to the government and health professionals.”
WebMD, Information and Resources Top 10 Most Prescribed, Top Selling Drugs 2014
In this chain of Endocrine-Immune-Biome Disruption resulting maladies, it is not that any one expression is skyrocketing. The concern is over the fact that ALL of the maladies in this chain are both connected AND skyrocketing; in the last 20 years in particular. EIBD is not a disorder, as a disorder is a condition a person has or inherits as part of their individual makeup. This malady is a disruption, because really almost everyone is now experiencing it to one degree or another and its impetus comes from outside factors invalidly affecting body systems. But just what are those factors? The Social Skepticism movement has been hired to desperately block the data collection, hypothesis development, testing and peer review necessary in you finding out. Rest assured that they will do anything – anything, to perform this role. But their battle is already being lost, through the most recent advances in science. In particular, some of the advances in the causes of cancer, are shedding light into the chain reaction of maladies which occur in the human body as a result of the introduction of auto-immune inducing environmental influences. Why is pancreatic cancer skyrocketing 5:1 in just the last 10+ years? (see: 
Repeat this over and over until you feel better. I can show you 64 media articles where various spokespersons repeat this statement over and over too, if you like. You will be guaranteed to feel much better. Lots of talk about “studies” and “science” and India growing GMO “crops” (cotton in fact, but implying that they are growing GM Food). So whatever you are observing to have happened in the last 15 years, it is a mirage, a manifestation of irrationality. Move along. If you are concerned about our food supply, then you are anti-GMO, irrational and anti-science. It is not the food. You just inherited a strange physiology, are deluded by fringe groups, and need to exercise more and eat less; and remember, avoid your “triggers.”
I find it interesting that in contrast to the Big Agra example with Bt/Stack Maize, Colgate, which sells a toothpaste containing 0.3% Triclosan, in their defense of the employment of the ingredient, cited several things about testing for human consumed products: