Never Never Land: Where we Send our Vaccinial Generation to Forget They Even Exist

Never Never Land Children, the Vaccinials, as of 2008 births, are 1 in every  55  39  36 28 kids – and rising. Meanwhile our fake skeptics dwell in a propter hoc ergo hoc solus fairy tale of their own crafting.
By 2060, my team preliminarily estimates that in excess of $185 Billion US Dollars will be spent by US families (not the US Government) in an effort to care for their adult cerebral injury children. Each year we currently add 35,000 new fully disabled (not simply Autism Spectrum Disorder diagnosed) children to these upcoming burden rolls. Let us be clear: this cost was shifted to American families by a corrupt government, agri and pharma infrastructure. It is a hidden cost today, borne by parents who will not always be around to care for their adult live-in-home children. And no, we did not simply miss or miscount these children back in 1970.

These are the forgotten generation of kids.  These are The Vaccinials (1994 – 2017)

Be forewarned. No manner of one-liner, exclusion biased study, nor conflict of interest voice of ‘skepticism,’ is going to be able to counter the will, acumen, organization and anger of this group of informed-activist parent.

Never Never Land: Where We Send Our Cerebral Injury Children to Pretend that Our Science is Ethical and Complete

autism never never landCurrently, 83% of adults with autism live with their aging parents (see: DisabilityScoop: Few Young Adults with Autism Living Independently). If you are in the social skepticism community, you deny most statistics about autism, especially if they originate from a group who studies autism or supports its injury focused community and their parents. The subject is a big threat to your clients. If you have an autistic child, and you do not toe the line of ‘wondrous genetic diversity’ and ‘disorder with no cause’ pseudo-science, rest assured that in today’s perverse political hack climate, you may be regarded by the holier-than-thou among us as an ‘anti-science’ rabble rouser, worthy of the highest disdain a memorized talking points sheet can muster.  There are those appointed to patrol forums and social media, to ensure that your voice is never heard, or if it is, that you pay a dear price for speaking up. Is it any surprise that the fake skepticism movement threw its hat into the ring of industry protectionism, before the science was even in, on this critical issue facing American families? Not to me. Perhaps it was part of their effort to support forces who want to cap Federal assistance to adults with autism (new rules can be found at 42 CFR Part 430 et seq and here), by denying that autism is increasing at all. A disorder group which used to be so rare that most Americans had never heard of it, now hitting every 7th house on our street and in our neighborhood overall. But according to skeptics, the increase only exists in our collective heads. Problem solved, we can all go home and relax. Parents, victims, adult sufferers are angry, questioning and not sitting down for the memorized set of talking point doctrine, as exemplified by the following industry propaganda:

“There is no doubt that the number of autism diagnoses has increased in the last two decades, but the evidence strongly suggests this increase in an artifact of how autism diagnoses are made, and not representative of a true increase.” – Steven Novella, Autism Increase Continues to Only Stem from Diagnosis Changes

Let’s be clear here. Steven is not arguing whether or not Autism Spectrum Disorders exist. No one is arguing this. What is being argued against here is the idea that these injuries should be examined scientifically for their cause. If there exists no associative increase, there is no necessity to examine cause. The occult mission of deception. I can avoid liability for my clients by citing that the burden of the $185 billion in care for the injured should fall on the shoulders of the parents who had the quirky DNA in the first place.

The study he references (‘a) does not contain evidence – rather a set of case studies, and neither does the ‘evidence’ ‘strongly suggest’ anything. It merely presents an argument for consideration. Fake skeptics accept such studies as proof when they like them, and reject them as anecdote when they do not. Ethical skeptics are students, observers of such chicanery on the part of fake skeptics. Steven has hammered such fallacious logic in arguments he does not favor; but here does not even catch it, when in his favor. The bare essence of conflict of interest.

Oligarch Skepticism is advocating that we should regard the phenomena under a business-as-usual policy: “We’ve slipped by without fault so far, so why should things change now?” i.e. ASD as simply a natural expression of genetic diversity, manifesting mostly in certain genetics, through no particular cause – there is no need to look any further. Those unfortunates who are harmed simply must bear this on behalf of the rest of us; without recourse, without recognition, without help. Never Never Land.

Ethical Skepticism says: Bullshit. This is what is called a ‘pretense of doing science’ or pseudoscience. Or what is also known in the philosophy of science as Manipulative Rational Ignorance:

Manipulative Rational Ignorance

/philosophy : science : pseudoscience : rhetoric : argument/ : a form of rhetoric wherein an arguer contends rational ignorance applies inside an argument, or the ignoring of a pathway of science because the cost or effort entailed is too high versus the results or lack thereof to be obtained from the effort. When in fact the arguer in reality fears the cost or penalty which would be incurred should the outcome of the scientific effort result in an observation or conclusion which he fears.

Of course, don’t take my word for it as a highly involved observer, but rather some who have done professional research on this very question as well (courtesy of the pragmaticalskeptic):

“The quantitative comparison of IDEA snapshot and constant-age tracking trend slopes suggests that ~75-80% of the tracked increase in autism since 1988 is due to an actual increase in the disorder rather than to changing diagnostic criteria.” ~ Nevison, C. (2014)

“These estimates suggest that at least part of the increase in autism diagnoses, about 50–65%, reflects an increase in the true prevalence of the disorder.” ~ Dave, D., Fernandez, J. (2014)

“Results suggest that among professional psychologists with a terminal degree (n=88), the majority believe that diagnostic changes can not fully account for the observed increase; 72% reported wither the true rate may have, or definitely has, increased.” ~ DeSoto et al. (2013)

“Published in the January 2009 issue of the journal Epidemiology, results from the study also suggest that research should shift from genetics to the host of chemicals and infectious microbes in the environment that are likely at the root of changes in the neurodevelopment of California’s children.” ~ Hertz-Picciotto et al. (2009)

No, these children were not slipping by under the old methods of diagnosis. The lack of ASD diagnosis in 1990 was not going to also mysteriously develop that erstwhile 1990’s child to the point where they can tie their shoes at age 14 or suddenly qualify to go to college.

No, this malady, this Autism Spectrum Disorder, AND the ensuing number of unequivocal under any contextfully disabled children (Level 3/Severe/Profound) is on the increase as well.¹ ² This cannot stem from a ‘change in diagnosis protocols’ as these severe diagnoses were always manifest.

One might, and that might requires a ton of evidence more than our ‘skeptics’ currently hold, might claim increases in diagnostics based upon hair-shade different methods of how mild symptoms are categorized, or through their co-diagnosis. But when there is no doubt as to an autism diagnosis, and there is no doubt as to its fully disabling impact, and statistics of this ilk are on the dramatic increase as well – then you know that a segment of the industry, habitually compensated to defend two specific industry verticals from tort risk, is boasting when they make this ‘substitution diagnostics’ claim. (’a Dev Med Child Neurol. 2008 May) In a logical calculus, a scientific reduction critical path, this claim is an impossibility. A soulless and predictable smokescreen.

Nonetheless, let’s examine this claim to knowledge and evidence further. Two factors override the necessity of making such a claim that we should just ignore autism growth rates and not seek a causative factor other than ‘wonderful genetic diversity.’

I.  The diagnosis ‘substitution’ claim is Incompetent, Ignorant or Malevolent depending upon the practices used to arrive at its conclusion.

Where Did the asd diagnoses come fromSo what do Dr. Novella and the case study he cites mean when they make the claim of ‘diagnosis substitution?’ In fact, Dr. Novella’s ‘theory’ is developed off of a single suggestive study of 38 people (’a Dev Med Child Neurol. 2008 May) and a data review of 670,000 children born between 1980 and 1991 in Denmark. The authors of many articles which have sprung up since have attempted to propose through these two suggestive anecdotes that ‘Language Disorders’ were employed as a ‘substitution diagnosis’ (in the DMCN 2008 study’s expression and definition) in lieu of what today would be diagnosed as ‘mild to moderate ASD.’ More recent analysis has served to disconfirm this. ‘e

These trends did not support the hypothesis that diagnostic substitution for ID can explain the ASD rise over recent decades, although the hypothesis appeared more plausible when the data were aggregated across all states and ages.

~ C.D. Nevison, M. Blaxill, Diagnostic Substitution for Intellectual Disability: A Flawed Explanation for the Rise in Autism (Sep 2017)

Notice the Simpson Effect which shows inside this data and is common to most autism statistical studies. In general, there are three forms of diagnosis substitution which are recognized; albeit the final form constituting simply a form of retired ignorance and not in reality a proposed substitution. When the article writers all get in a froth over fictitious growth, they more than likely mean ig-diagnosis. The simple fact is that ig-diagnosis only appears to hold up under a cursory examination of the evidence. The three forms are per below: Ex-diagnosis, co-diagnosis and ig-diagnosis.

What Did Not Happen

what did not happen ex diagnosis1. Ex-diagnosis – this claim species contends that other malady populations, under a new and better understanding of symptoms and etiology, are now categorized within new malady sets. This is observed by citing a drop in diagnoses rates of the older understood malady, commensurate with an exact and inversely proportional signal rise in the newly understood diagnostic malady.

FALSE -Neither the signal trends, nor the underlying increase figures allow for a mathematical possibility of an ex-diagnosis situation.

a. No malady sets, bearing a confusion with ASD symptom sets, have decreased – they have all risen dramatically as well. Certainly not a single one has decreased in inverse proportion signal to the rise in ASD diagnoses.

i. The Annual Increase in ASD cases:   89,000 New cases each year.  A 218% growth in occurrence.¹ ² Meanwhile,

ii.. Epidemiology of non-autism Intellectual Disabilities shows an aggregate growth in all categories of 93% between 1970 and 2014 including: ¹ ² ³ ∈ ’b ’c

“Mental Retardation” “Developmental Delay or Language Disorder” and “Other Encephalopathies and Palsies” rose from a 1970 rate of 2.75% of the population to a current 5.4%. The criteria for these (IQ <70) – has not changed in the last 45 years.

b. If this practice set were the case, we should have seen a sympathetic signal rise in the number of Cerebral Palsy cases, as the understanding of its subtle forms also became manifest and appropriately categorized in parallel to ASD. We did not indeed observe such an effect with Cerebral Palsy.

what did not happen co diagnosis2. Co-diagnosis – Under this claim species, older indistinct malady sets, such as language impairment or mild mental retardation, are now diagnosed coincident with new diagnoses falling within a new understanding of the ASD spectrum. In other words, under this claim what was once diagnosed as a language delay, is now diagnosed as both a language delay AND autism.

FALSE – No co-diagnosis signal has been observed in the trend and every single co-diagnosis malady is also rising at an alarming and ‘naturally occurring from the environment’ curve signal.

a. If this were true, we would have seen a discrete rise in diagnosis during the 2 years it would take to get the new diagnostic protocols (Autism Diagnostic Observations Schedule – ADOS) into the hands of nationwide medicine professionals (see collapse of ulcers in 2006). We would have seen a discrete rise in ASD diagnoses the very two years in which this new understanding was promulgated, and upon each iteration thereof. Indeed we did not, and have not seen such a signal at all – quite the contrary. The diagnoses have risen along a trend signal characteristics of an outside environmental influence. ¹ ² ³ ∈ ’b ’c

b. Every pairing of coincident malady set, LD/ASD, MR/ASD have seen BOTH maladies in the pairing rise despite their co-pairing. Under the co-diagnosis scenario, ONLY the newly coincident diagnosis rises, when in fact, this has not been the case at any time during the 1970 – 2014 measured horizon of new autsim (see above). ¹ ² ³ ∈ ’b ’c Given that language and other developmental disabilities have risen to affect up to 15% of the US 3 – 17 year old population in recent years, (‘d) this is going to be a daunting claim to substantiate.

c. If this practice set were the case, we should have seen a sympathetic signal rise in the number of Cerebral Palsy cases, co-diagnosed with LD and mild MR. We did not indeed observe such an effect with Cerebral Palsy.

what did not happen ig diagnosis3. Ig-diagnosis or Combination of all three – Under this claim species, in older days, the malady sets now observed were ignored as just normal childhood challenges and were not categorized into any distinct symptomology or malady group. The ig-diagnosis option, includes any form or variant of a combination of all three – ex-diagnosis, co-diagnosis and ig-diagnosis.

FALSE – No ig-diagnosis signal has been observed in the trend and the most severe forms of ASD (unmistakable under any context of timeframe) are also rising at an alarming and ‘naturally occurring from the environment’ curve signal.

a. If this were true, we would have seen a discrete rise in diagnosis during the 2 years it would take to get the new diagnostic protocols (DSM III, IV and V as well as Autism Diagnostic Observations Schedule – ADOS releases) into the hands of nationwide medicine professionals (see collapse of ulcers in 2006). We would have seen a discrete rise in ASD diagnoses the very two years in which this new understanding was promulgated. Indeed we did not, and have not seen such a signal at all – quite the contrary. The diagnoses have risen along a trend signal characteristics of an outside environmental influence. ¹ ² ³ ∈ ’b ’c

b. The simple fact is that our disabled autism group of young girls and boys has grown – 43% since 1990 for ASD and CP causes combined. ¹ ² ³ † And our annual contribution of newly diagnosed group of fully disabled (severe and profound categorizations) autism/ASD kids has grown a whopping 1500% since pre-1990 rates.² ‡ That is 35,000 kids a year we just missed in 1980. Sure. Right. In other words, for the ig-diagnosis scenario indeed the case – it is mandatory that the yellow band on the graph to the right and the yellow line on the actual rates graph below (Level 3, severe and profound cases) stay within its traditional bounds. This in fact, has not occurred.

c. If this practice set were the case, we should have seen a sympathetic signal  rise in the number of Cerebral Palsy cases, as the understanding of its subtle forms also became manifest and appropriately categorized in parallel to ASD. We did not indeed observe such an effect with Cerebral Palsy.

What Did Happen

True Rise in AutismChoose your poison – claims of substation diagnoses are ones of Incompetence, Ignorance or Malevolence. The claim rises nowhere near to the lever of rigor or analytical support base commensurate with something regarded by science as a ‘theory’ (see pseudo-theory). I seriously doubt that our doctors in 1990 were counting this malady as some other or no other disorder altogether. That contention would shed a light of incompetence on medicine that Science Based Medicine has claimed does not exist. No, this set of data entails an addition of 89,000 new cases of ASD each year, currently and rising. (Please note that the ‘slow’ periods on the blue line in the graphic to the right, are not really periods of slowing – rather simply periods of time in which we simply did not look).

Were this rise to have been an effect of newly released protocols, we should have seen bumps in diagnosis of ONLY MILD ASD commensurate with the release of the new guidelines. We have not. What we have seen is what is called an ‘environmentally induced’ curve in BOTH mild ASD as well as Level 3 diagnoses – moderate, severe and profound. All categories are rising, and there never has been a protocol basis for mistaking severe and profound autism. Yet this category is rising too. Neither will parental interview forms (2001’s ADI-R for instance) contribute to this category.

If protocols and collection methods were to blame, we should see a 1500% rise in mild autism with only a nominal rise in Level 3 autism. In fact, we have seen just the opposite – a more robust rise in unmistakable-under-any-protocol severe autism.

Comparatively, all other cognitive diagnoses have failed to decline by this commensurate rate or amount – contrary to what Dr. Novella is implying above. Cross contributions cannot possibly account for the rise in ASD, much less the rise in persistent, severe and profound cases of ASD. This contention is simply a case of wishful thinking, probably stemming from lack of a suitable sample horizon on the part of the Dev Med Child Neurol. 2008 May study referenced. I understand and sympathize with this desire to find perhaps a reassuring comfort to the challenge of growing autism, in that somehow it does not exist. But we are all better if we ethically face the reality of science and the supremacy of precaution, as a society. However, thankfully the Centers for Disease Control is well underway on a study to examine this very issue inside the Study to Explore Early Development (SEED).(‘d)

Our parents of autistic and ASD children are demanding more than what Dr. Novella has offered. I await more detail from this CDC SEED study before I could think to make a Novella style ‘strongly suggests’ countermand of the precautionary principle regarding ASD, especially if I were a media ‘science communicator’ and doctor in the public view. The Novella claim of ‘strongly suggests’ is not reality. Were Dr. Novella to petition the CDC and SEED team for specific studies of a specific nature to follow up this observation set, I would respect and be in full support of such advocacy. Curious that he does not. He would rather draw a conclusion. Sound familiar? Science is a method. Posturing is pseudoscience.

Each of these claims, ex-diagnosis, co-diagnosis and ig-diagnosis are extraordinary claims, if indeed this is what we are to infer from Dr. Novella’s new ‘theory’ he is touting on behalf of the pharmaceutical industry.

Meanwhile, consilient data (yes science) arrives from other disciplines and approaches which corroborate this inferred increase in the rate of ASD and related encephalopathy. There is NO MISIDENTIFYING disabling levels of encephalopathy. None. And to presume that this stark increase – relates simply to a change in diagnostic protocols becomes more and more each year, as the curve in the graph above continues to rise, a malevolent fantasy played out at the expense of innocent children and their parents. History will not be kind to Dr. Novella. We here, are just ahead of the curve.

And since the evidence virtually falsifies the ‘theory’ he is touting – Ockham’s Razor dictates that it should not be added as a theory.

A parent with an autistic child, or those who study the prevalence of moderate, severe and profound categorizations, might respond to each of the three species of substitution with the technical term: Bullshit. Parents of ASD children know now, and would have known in 1970 as well, that this is much more than simply an issue of ‘language delays.’ The only reason this idea survives is because of the relative ignorance about autism on the part of the general audience population and their gullibility towards self-proclaimed ‘science communicators’ in the media. Spinning plausible – propter hoc ergo hoc solus – (I have proposed a plausible counter-explanation so now no further study is warranted) explanations for phenomena they are wishing to deny, is a master skill of those majoring in skeptic quackery.

If on the other hand, indeed the rise in ASD is simply a case of ‘substitution diagnoses’ – then something extraordinary is going on because all versions of Intellectual Disability (led by language developmental delays) have grown in rate 93% over the last 25 years. ∈ ’a ’b If we debit the ASD side of the balance sheet, and credit the former Developmental and Language Delay side, we have simply shifted the argument to a broader playing field – and not resolved the primary concern.

At best, if I really cheat to support it, the ‘substitution diagnosis’ claim is simply an etiological magic trick, shifting the argument cleverly into another reductive domain.

II. I don’t have to ‘prove’ any of this in finality in order to demand action/real science accountability from the two risk bearing parties.

One of You is LyingMoreover, the simple fact is, I do not have to ‘prove’ a connection here, in order to demand action in the first place. There are only two risks of dependency in relation to Autism Spectrum Disorders as we are experiencing them today: pharmaceuticals or pesticides administered during the first 18 months of life. That is it. One or both of these groups is lying about a contributory factor. The signal runs parallel as a matter of fact to 17 other maladies currently on the exponential or arithmetic increase. To deny this is simply obdurate stupidity. Cowardice. The worship of career, status and money, over ethics and service to mankind.

Yes it is not as simple as post hoc ergo propter hoc. But neither is it as simple as ‘let’s ignore it and see if it goes away.’ The latter default artifice is the true fallacy.

The burden of proof, whether under a hypothesis reduction, or even in light of the precautionary principle, has been shifted. Plurality has been established and the onus is now on those two industry verticals to prove their innocence. Prove it with real – and thorough science. No, saving dollars is not a sufficient argument of necessity to approve a science prematurely. Neither is ‘feeding the world.’ Efforts to squelch this research are the only means left at the disposal of the oligarch. These are the tactics in this case, of one who does not really understand science, or even worse, is participating in a corruption-in-ignorance.

The burden of proof has been shifted. Claims that ASD increases are fictitious, only serve to shift the argument context via a form of very familiar hand-eye magician trick. These are the last resort claims one makes when undertaking extraordinary measures to block science. Science which threatens one’s clients.

Clients who now owe us all an answer, supported by real science.

Never Never Land: Where We Send Our Cerebral Injury Children to Pretend that They Don’t Bear a Cost

Our current rate of newly diagnosed Never Never Land Children, as of 2008 births, are 1 in every  55  39  36 kids – and rising. Even if we freeze the increase at this 2008 rate, we will need to be building 80+ care centers a year by 2036, to take care of even a conservative portion of these abandoned children..

autism raw numbers growthHere are the facts. At the current rate of rise in persistent moderate, severe or profound autism, annually in the United States we will diagnose as of 2014, 89,000 new victims of Autism each year. This is 218% higher than the same rate measured in 1990. And remember, that cases of persistent, moderate, severe and profound autism are growing commensurate with this aggregate rate. These are diagnoses which could not have been overlooked as simply speech delays in 1990. The contention that this rise is simply a case of substitution is impossible in any frame of logical calculus.

In addition, the Centers for Disease Control have made it clear that the autism diagnosis epidemiology contains a heavy genetic factor component.¹ ² Victim families tend to cluster into specific genetic groupings. Statistics which are easily watered down or hidden inside the suspect method and data of large aggregate studies, and an abject refusal to follow up or examine the excluded data group itself, or any focused subsets of inclusion. With large studies or big data, we can just issue a meta-analysis and call the science ‘finished consensus.’ Baloney. Clueless, no observation, baloney.

The simple fact is that, even with only the current 35% rate of full intellectual disability,‡ and a 16.8% employment success among the intellectually disabled,‡ that there remains an annual 35,000 ASD and CP group each year who will never be able to live outside their parents’ homes for the remainder of their parents’ lives. ¹ ² ³ ‡  The cost burden on these genetic subsets of families and society is enormous, currently in the $260 billion USD range, according to the Autism Society.‡ That is $74,300 per every family with an autistic child, per year, with a good 30-50% of this burden borne directly by those household budgets in terms of special education, special medical services, and accommodations for life of resident care/no employment.

Now the good news is, that only 35% of ASD victims are permanently unable to work. A portion of ASD victims can recover in part and some attend college and take on professional careers.  If we weight-combine this 35% ASD disability with the 100% disability profile of cerebral palsy, we obtain an aggregate 57% rate of disability among the ASD/CP population. Additional good news can be found in that 16.8% of these disabled individuals can still obtain some form of employment. Unemployment is 83.2% in this category of individual.‡ This means that, our true group of concern, our individuals who will be left destitute if not cared for by a head of household, is much lower than the overall rate of ASD/CP diagnosis.

But still, this group of the potentially destitute ASD/CP injured grows at a rate of 35,000 people annually, for those born in 2006. The overwhelming majority of these individuals live with their parents in their family home until their parents pass on.

This is is how the industry hides the burden currently. Both they and the government shifted the burden to the victim families and pretend that the cost does not exist. We are so scientific! But, beginning in 2020 they will not be able to hide The Hollowcost much longer. They think the ‘anti-science’ screaming is shrill now? Just wait until phase II of the deception kicks into high gear, per below.

Never Never Land: Where We Send Our Cerebral Injury Children to Pretend that They Never Grow Up and Their Parents Never Die

In similar burden, this condition only exists as the honeymoon period of the age of autism in which we exist. What our experts have ignored to date is the upcoming economic burden of caring for these children, who cannot live outside their parents’ homes, at a future date when those parents are retired, disabled or deceased.  This is The Hollowcost we have ignored.

Based on current rates of persistent, severe or profound autism, along with cerebral palsy cases, our annual rate of contribution to this growing group of individuals is projected at:

      The Future Cost of Caring for Disabled ASD and CP Kids (now borne by living parents)

autism future care burden and costA total annual household burden exists today in the range of $26 Billion USD‡, just to currently bear the needs of our autism spectrum and cerebral injury children. That equates to around $35,000 per year for life for every single individual currently diagnosed as disabled autistic or cerebral palsy, in terms of today’s cost in the home of their parents.  A cost which the pharmaceutical and agriculture industries pretend does not exist. But that is just today’s cost.

The chart to the right is developed from actual long term care residency center profit & loss statements and their established trends.  It reflects a projected $186,000 a year cost, in terms of 2060 dollars, for resident life in a full autism/CP care-residency center. Here is what the average family would need, after retirement in assets at death, in order to care for the average ASD/CP child under this context – once there is no longer a home/parents to take care of them. This is what they have to start saving for NOW.

$ 2,100,000    USD liquid estate in 2060, earning at 4.0 – 5.0% post tax, for every disability autistic or CP child left behind when the parents die.

94% of American families with Autistic and CP children will not be able to handle this burden when it arrives. And no, our current costs of insurance, healthcare and taxation rises will not allow these families to keep their homes after the parents pass on. These kids have to go somewhere.

Congratulations to our pharmaceutical and agricultural verticals. A case study in how to NOT perform economic and risk analysis. We now see the full cost of efficiency and risk, when it is tucked inside of fake studies, incomplete science, failure to follow up, disregard for the precautionary principle, fake numbers, politically correct fake skepticism, shill advocacy – all risk-shifted off to those who we do not acknowledge exist, timeframes which we pretend do not exist and money budgets we consider to be endless. To continue to protect the institutional verticals which are creating this phenomena (and only two bear a risk relationship to it), in the name of efficiency and ignored risk, is the height of obdurate cruelty and ignorance.  This will serve to bite us in the ass as a nation. In 2060, the voices screaming today that there is ‘no increase in autism or cerebral injury’ will be considered with the same disdain as is currently held for the fascist and genocidal dictator of the 20th Century. This is not an instance where flippantly regurgitating a one-liner about Godwin’s Law applies; rather it is a sobering and upsetting reality, only excused inside the heart of the most cruel, corrupt or self centered among us.

As as I usually observe in such situations, where were the ‘skeptics’ when all this evolved as material questions of science? Where were the skeptics?

Never Never Land.

epoché vanguards gnosis


¹  Department of Health and Human Services, National Center for Health Statistics, web: http://www.dhhs.gov. Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System:

²  Centers for Disease Control and Prevention: Autism Spectrum Disorder Prevalence, http://www.cdc.gov/ncbddd/autism/data.html.

³  Centers for Disease Control and Prevention: Data and Statistics for Cerebral Palsy, http://www.cdc.gov/ncbddd/cp/data.html.

†  Dev Med Child Neurol. 2014 Jan;56(1):59-65. doi: 10.1111/dmcn.12268. Epub 2013 Oct 1. Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor functioning – Autism and Developmental Disabilities Monitoring Network, USA, 2008.

‡  The Autism Society, Autism and Autism Based Disability Facts and Statistics, http://www.autism-society.org/what-is/facts-and-statistics/

∈  State Specific and Aggregate Rates of Mental Retardation, United States, http://www.cdc.gov/mmwr/preview/mmwrhtml/00040023.htm

’a  Dev Med Child Neurol. 2008 May;50(5):341-5. doi: 10.1111/j.1469-8749.2008.02057.x. Epub 2008 Mar 31. Autism and diagnostic substitution: evidence from a study of adults with a history of developmental language disorder. Bishop DV1, Whitehouse AJ, Watt HJ, Line EA.http://www.ncbi.nlm.nih.gov/pubmed/18384386?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

’b  Centers for Disease Control and Prevention: MMWR Weekly Jan 26, 1996, http://www.cdc.gov/mmwr/preview/mmwrhtml/00040023.htm.

’c  Cornell University Disability Statistics Resource Database, https://www.disabilitystatistics.org/reports/acs.cfm?statistic=1.

’d  CDC currently is funding and collaborating on the Study to Explore Early Development (SEED), one of the largest U.S. studies to help identify factors that may put children at risk for autism spectrum disorders and other developmental disabilities. We also are exploring risk factors for and investigating causes of developmental disabilities through other national and international collaborations.http://www.cdc.gov/ncbddd/developmentaldisabilities/about.html

‘e  C.D. Nevison, M. Blaxill, Diagnostic Substitution for Intellectual Disability: A Flawed Explanation for the Rise in Autism; Sep 4, 2017 ;https://www.ncbi.nlm.nih.gov/pubmed/28589495

Notes (with thanks and full credit to) from PragmaticalSkeptic

pragmaticalskepticThis is an incredible write up, TES. To add to what you wrote, here is more relevant science regarding the epidemic of autism:

Nevison, C. (2014). a comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors. Environ Health, 13(73). Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177682/

“The quantitative comparison of IDEA snapshot and constant-age tracking trend slopes suggests that ~75-80% of the tracked increase in autism since 1988 is due to an actual increase in the disorder rather than to changing diagnostic criteria.”

Dave, D., Fernandez, J. (2014). Rising autism prevalence: Real or displacing other mental disorders? Evidence from demand for auxiliary healthcare workers in California. Economic Inquiry. Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/ecin.12137

“These estimates suggest that at least part of the increase in autism diagnoses, about 50–65%, reflects an increase in the true prevalence of the disorder. (JEL L11, J2, J3)”

DeSoto et al. (2013). Professional opinion on the question of changes in autism incidence. Open Journal of Psychiatry. Retrieved from http://www.scirp.org/Journal/PaperInformation.aspx?paperID=30182

“Results suggest that among professional psychologists with a terminal degree (n=88), the majority believe that diagnostic changes can not fully account for the observed increase; 72% reported wither the true rate may have, or definitely has, increased.”

Hertz-Picciotto et al. (2009).UC Davis M.I.N.D. Institute study shows California’s autism increase not due to better counting, diagnosis. UCDavis Health System. Retrieved from http://www.ucdmc.ucdavis.edu/welcome/features/20090218_autism_environment/

“Published in the January 2009 issue of the journal Epidemiology, results from the study also suggest that research should shift from genetics to the host of chemicals and infectious microbes in the environment that are likely at the root of changes in the neurodevelopment of California’s children.”

The Urgent Need to Reform the ABCD Seed Cartel Science Around Glyphosate

The Largest Single Health Damaging Event in American History

and where were our ‘skeptics’ for the last 24 years while this occurred? Chasing ghosts, Bigfoot and UFO hunters…

glyphoseatIt has always been more than simply interesting that our 1995-genesis epidemics of gluten sensitivity and IBS just mysteriously happened to coincide with our introduction of glyphosate into 95+% of the wheat, corn, soy and canola food supply. But if that were the only two flash-skyrocketing maladies the American public has suffered since 1995 then my curiosity might not have been piqued. And let’s be clear, Americans are the heaviest consumers of glyphosate, and are for the most part, the ones suffering most from these new top 10 prescribed-for epidemic maladies. Parsimony under an ethical governance of science, would dictate plurality due to observation, relationship and risk, under the scientific method. However, it has taken the sickening of our entire nation to alert us to this horrendous act.

Why? Because of corrupt oligarch influence and fake skepticism, plain and simple. The act of blocking or not skeptically researching the impact of glyphosate on our collective intestinal health since 1995 – is unconscionable pseudoscience. This should be pursued by a class action lawsuit – god knows that my family has suffered enough from this malfeasance and incompetence.  Your claims that we are anti-science be damned. On the contrary, science is stepping back in and taking control back from this case study in corruption.

There are six compelling reasons why the science performed to date on Glyphosate is woefully insufficient, and re-disposition by the EPA, through complete science performed by neutral third parties regarding Glyphosate and its enabling GMO seed monopoly, should be once again evaluated.  The scientific method does not dictate that preliminary conclusions, once published, can never again be examined just because SSkeptics declare otherwise.  In fact, Ethical Skepticism demands that we re-examine the role of this harmful technology in American diets and in overall human and ecological health.

Glyphosate

/ N-(phosphonomethyl) glycine / : Herbicide, assigned EPA Human Toxicity Category III and WHO Toxicity Group 2A ‘probably carcinogenic to humans.’ Toxicity enabled to varying levels in different species, by acting as a water soluble analog of the protein glycine, which deleteriously interferes with the synthesis of the aromatic amino acids phenylalanine, tyrosine and tryptophan; effectively killing bacteria and plants which depend upon the EPSP Synthase pathway. A dependency based technology utilized by Monsanto to establish a strategically planned seed sourcing monopoly. This an outcome of Glyphosate’s complimentary relationship with patented GMO seed modifications, enforced for use throughout a compliant ABCD Seed Cartel,‡ regarding Glyphosate tolerance.

Glyphosate Use Originally Approved/Mandated Under Outdated and Incomplete Science. Which now shows alarming real world test data, to wit:

Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement

Environmental Health201615:19 DOI: 10.1186/s12940-016-0117-0 ©  Myers et al. 2016 Received: 8 June 2015, Accepted: 6 February 2016, Published: 17 February 2016

We conclude that: (1) GBHs are the most heavily applied herbicide in the world and usage continues to rise; (2) Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions; (3) The half-life of glyphosate in water and soil is longer than previously recognized; (4) Glyphosate and its metabolites are widely present in the global soybean supply; (5) Human exposures to GBHs are rising; (6) Glyphosate is now authoritatively classified as a probable human carcinogen; (7) Regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science.

Genetically engineered crops, glyphosate and the deterioration of health in the United States of America

Journal of Organic Systems, 9(2), 2014; ISSN 1177-4258

Abstract

A huge increase in the incidence and prevalence of chronic diseases has been reported in the United States (US) over the last 20 years. Similar increases have been seen globally. The herbicide glyphosate was introduced in 1974 and its use is accelerating with the advent of herbicide-tolerant genetically engineered (GE) crops. Evidence is mounting that glyphosate interferes with many metabolic processes in plants and animals and glyphosate residues have been detected in both. Glyphosate disrupts the endocrine system and the balance of gut bacteria, it damages DNA and is a driver of mutations that lead to cancer. In the present study, US government databases were searched for GE crop data, glyphosate application data and disease epidemiological data. Correlation analyses were then performed on a total of 22 diseases in these time-series data sets.

The Pearson correlation coefficients are highly significant (< 10-5) between glyphosate applications and hypertension (R = 0.923), stroke (R = 0.925), diabetes prevalence (R=0.971), diabetes incidence (R= 0.935), obesity (R = 0.962), lipoprotein metabolism disorder (R = 0.973), Alzheimer’s (R = 0.917), senile dementia (R = 0.994), Parkinson’s (R=0.875), multiple sclerosis (R=0.828), autism (R= 0.989), inflammatory bowel disease (R = 0.938), intestinal infections (R = 0.974), end stage renal disease (R = 0.975), acute kidney failure (R=0.978), cancers of the thyroid (R = 0.988), liver (R = 0.960), bladder (R = 0.981), pancreas (R = 0.918), kidney (R = 0.973) and myeloid leukaemia (R = 0.878).

The Pearson correlation coefficients are highly significant (< 10-4) between the percentage of GE corn and soy planted in the US and hypertension (R = 0.961), stroke (R = 0.983), diabetes prevalence (R =0.983), diabetes incidence (R = 0.955), obesity (R= 0.962), lipoprotein metabolism disorder (R =0.955), Alzheimer’s (R = 0.937), Parkinson’s (R = 0.952), multiple sclerosis (R = 0.876), hepatitis C (R= 0.946), end stage renal disease (R = 0.958), acute kidney failure (R = 0.967), cancers of the thyroid (R = 0.938), liver (R = 0.911), bladder (R = 0.945), pancreas (R = 0.841), kidney (R = 0.940) and myeloid leukaemia (R = 0.889). The significance and strength of the correlations show that the effects of glyphosate and GE crops on human health should be further investigated.

Shehata AA1, Schrödl W, Aldin AA, Hafez HM, Krüger M.; Curr Microbiol. 2013 Apr;66(4):350-8. doi: 10.1007/s00284-012-0277-2. Epub 2012 Dec 9.

Abstract

The use of glyphosate modifies the environment which stresses the living microorganisms. The aim of the present study was to determine the real impact of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. The presented results evidence that the highly pathogenic bacteria as Salmonella Entritidis, Salmonella Gallinarum, Salmonella Typhimurium, Clostridium perfringens and Clostridium botulinum are highly resistant to glyphosate. However, most of beneficial bacteria as Enterococcus faecalis, Enterococcus faecium, Bacillus badius, Bifidobacterium adolescentis and Lactobacillus spp. were found to be moderate to highly susceptible. Also Campylobacter spp. were found to be susceptible to glyphosate. A reduction of beneficial bacteria in the gastrointestinal tract microbiota by ingestion of glyphosate could disturb the normal gut bacterial community. Also, the toxicity of glyphosate to the most prevalent Enterococcus spp. could be a significant predisposing factor that is associated with the increase in C. botulinum-mediated diseases by suppressing the antagonistic effect of these bacteria on clostridia.

probased glyphosate drunk by each american each year - CopyGlyphosate interferes with :

Intestinal Dendritic Cell EPSP Synthase, effectively killing those critical immune system messenger cells as part of glyphosate’s well established EPSPS microbicide effectiveness. This renders the gut/immune system unable to communicate microbial tolerance to the innate and adaptive immune systems; effectively triggering celiac disease-like symptoms in humans, including nausea, diarrhea, skin disorders, macrocytic anemia, b-vitamin depletion, depression, IBS, IBD, rosacea and several other longer term chronic illnesses.

Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology. 2013;6(4):159-184. doi:10.2478/intox-2013-0026.

Phenylalanine – Elevates the mood, ensures good function of the autonomous and central nervous system (breathing, sleeping, calmness), essential for memory and learning and regulates the appetite by causing excess hunger until this minor protein is fulfilled. Otherwise one short of phenylalanine will overeat in order to attain minor proteins needed.

Tyrosine – It is a building block for several important neurotransmitters, including epinephrine, norepinephrine, serotonin, and dopamine. Neurotransmitters help nerve cells communicate and influence mood. Tyrosine also helps produce melanin (the pigment responsible for hair and skin color) and helps in the function of organs responsible for making and regulating hormones, including the adrenal, thyroid, and pituitary glands.

Tryptophan – The body uses tryptophan to help in the uptake of niacin (Vitamin B3 – lower cholesterol and triglycerides (types of fat) in the blood) and serotonin. Serotonin is thought to produce healthy sleep and a stable mood.

absorbed glyphosate is not excreted in urineGlycine – Essential for a healthy, normally functioning digestive system. It helps regulate the synthesis of the bile acid used to digest fats. Helps establish the mucosa barrier which blocks toxins from crossing the intestinal boundary – reduces the amount of auto-immune triggers in the blood.

Disruption of Kidney and Liver mRNA splicing and small nucleolar RNA – were mostly upregulated, suggesting disruption of normal spliceosome activity. Electron microscopic analysis of hepatocytes confirmed nucleolar structural disruption.

Disruption of Genes Controlling Chromatin Structure – Genes (especially histone-lysine N-methyltransferases) were mostly upregulated in Kidney and Liver measures.

Disruption of Genes Related to Respiratory Chain Complex I and the Tricarboxylic Acid Cycle – Pathway analysis suggests a modulation of the mTOR and phosphatidylinositol signalling pathways. Gene disturbances associated with the chronic administration of ultra-low dose Roundup reflect a liver and kidney lipotoxic condition and increased cellular growth that may be linked with regeneration in response to toxic effects causing damage to tissues.

Collectively – the interference with these proteins, DNA functions and elimination of vital gut flora causes in humans:

  • Loss of well being and up mood – creates anxiety
  • Endocrine function loss (Hypo-thyroid, Hypo-pituitary, Adrenal-Thyroid-Pituitary Axis)
  • Digestive screening loss and Auto-Immune flareups
  • Loss of protein synthesis in muscles
  • Loss of B vitamin uptake – especially in low-methylation genetic profile individuals
  • Higher triglycerides and cholesterol, liver stress
  • Chronic inflammatory diseases
  • Chronic digestive tract diseases
  • Liver pathology and morphology changes
  • Kidney pathology and morphology changes
  • Dysbiosis
  • IBS/IrBD
  • Disruption of cell’s ability to break down and burn sugars (diabetes)
Where were the SSkeptics when this was all approved inside 3 years? Busy ranting about supplements, ghosts, UFO’s, the Loch Ness Monster, alternative medicine and ulcers being caused by coffee and stress.
Glyphosate History Curve1.  The studies upon which EPA Approval was granted are based on preliminary and aged experimental observation.

EPA Initial Approval

1991     RED Facts: Glyphosate; EPA-738-F-93-011; U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 1993.

2.  The EPA Approval was granted on only one scant 1970 / 80’s study series, conducted on animals (rats, rabbits, beagles); wherein the objectivity is in question, of both the EPA and Monsanto in assessing the regulatory applicability of these early studies, as they were all completed only by Monsanto.

Approval Basis: All Monsanto Studies

autism and glyphosate - CopyReregistration Eligibility Decision (RED) Glyphosate; EPA-738-F-93-011; U. S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 1993. Referenced studies (Increase in autism study on right from Nevison, Environmental Health; 2014, 13:73 Page 4 of 16 : http://www.ehjournal.net/content/13/1/73).

1985     Reyna, M. Twelve month study of glyphosate administered by gelatin capsule to beagle dogs. Unpublished Report no. 830116, project no. ML-83-137, 1985, submitted to U.S. Environmental Protection Agency by Monsanto Company Environmental Health.

1983     Knezevich, A.; Hogan, G. A chronic feeding study of glyphosate (Roundup technical) in mice. Unpublished Report no. BDN-77420, project no. 77-2061, 1983, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by BioDynamics, Inc.

1970     Birch, M. Toxicological investigation of CP 67573-3. Unpublished Report no. 4-70-90, 1970, submitted to U.S. Environmental Protection Agency by Monsanto Corporation, prepared by Younger Laboratories, Inc.

1988     Blaszcak, D., Primary dermal irritation study in rabbits for glyphosate technical (wetcake). Unpublished Report no. BD-88- 114, project number 4887, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Corporation, prepared by BioDynamics, Inc.

1980     Rodwell, D. E.; Tasker, E. J.; Blair, A. M.; et al. Teratology study in rats. Unpublished report no. 401-054, unpublished study no. 999- 021, 1980, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by International Research and Development Corporation.

1980     Rodwell, D. E.; Tasker, E. J.; Blair, A. M.; et al. Teratology study in rats. Unpublished report no. 401-056, 1980, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by International Research and Development Corporation.

1988     Monsanto Corporation. The metabolism of glyphosate in Sprague Dawley rats- Part I. Excretion and tissue distribution of glyphosate and its metabolites following intravenous and oral administration. Unpublished report no. MSL-7215, 1988, submitted to WHO by Monsanto Ltd, prepared by Monsanto Environmental Health Laboratory.

1988     Ridley, W.; Mirly, K. The metabolism of glyphosate in Sprague-Dawley rats. Part I. Excretion and tissue distribution of glyphosate and its metabolites following intravenous and oral administration. Unpublished report no. 86139 (MSL 7215), RD no. 877, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Company.

1988     Howe, R.; Chott, R.; McClanahan, R. Metabolism of glyphosate in Sprague-Dawley rats. Part II: Identification, characterization, and quantitation of glyphosate and its metabolites after intravenous and oral administration. Unpublished report no. MSL-7206, RD No. 877, 1988, submitted to U.S. Environmental Protection Agency by Monsanto Company.

1978     Brightwell, B.; Malik, J. Solubility, volatility, absorption, and partition coefficients, leaching and aquatic metabolism of MON 0573 and MON 0101. Unpublished report no. MSL-0207, 1978, submitted to U.S. Environmental Protection Agency by Monsanto Company.

1990     McMullan, P.; Honeggar, J.; Logusch, E. Confined rotational crop study of glyphosate Part II. Quantitation, characterization and identification of glyphosate and its metabolites in rotational crops. Unpublished report no. MSL-981, 1990, submitted to U.S. Environmental Protection Agency by Monsanto Agricultural Labs.

1978     Fink, R.; Beavers, J. One-generation reproduction study in bobwhite quail: glyphosate technical. Unbpublished report no. 139- 141. 1978, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Wildlife International Ltd.

1982     McAllister, W.; McKee, M.; Schofield, M.; et al. Chronic toxicity of glyphosate (AB-82-036) to Daphnia magna under flow-through test conditions. Chronic toxicity final report ABC 28742. Unpublished report, 1982, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Analytical Bio-Chemistry Laboratories, Inc.

1974     Bentley, R., Acute toxicity of roundup (technical) to grass shrimp (Palaemonetas vulgaris) and fiddler crab (Uca pagilator). Unpublished report no. SF1536, 1974, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Bionomics, Inc.

1972     Frasier, W. D.; Jenkins, G. The acute contact and oral toxicities of CP67573 and MON2139 to worker honey bees. Unpublished report no. 4G1444, 1972, submitted to U.S. Environmental Protection Agency by Monsanto Company, prepared by Huntingdon Research.

pseudoscienc-isIn the instances of the third party labs which completed studies, subsequently routed through Monsanto to the EPA, a glance at LinkedIn and Moody’s shows that several of these companies were staffed by ex Monsanto and Syngenta employees, all in the St. Louis and Columbia, Missouri local area, or were small or one man or short lived businesses, operating around the period of the study. Nor did these firms continue their research after the EPA approval. A curious set of actions given that now human and higher order mammal and prodigious field data are available, which could improve their confidence interval risk profiles to an impeccable level of integrity. Yet they just ceased study altogether. This brings their third party objectivity, and their role as scientists, into essential question.

3.  The sample sizes of observational data for all coincident maladies is much more easily accessible/collectible today. As well, Monsanto coordinated the release of studies, patents and EPA approvals as part of a liability risk mitigation strategy regarding these maladies, along with its connected seed sourcing monopoly business strategy

Monsanto Strategy wth GlyphosateThe height of dishonestyAs you can see from the above graphic, the amount of human data available with which to truly assess the safety of Glyphosate, is on the order of 30,000 times as large as it was in the 1986 – 1991 timeframe in which the Approval studies were conducted.  In addition, the littany of condemning, or alarm raising studies continues to proliferate AFTER the Approval in 1991 by the EPA. See the listing below.

What Monsanto has accomplished here is brilliant strategy.  They planned the timed arrival of the Glyphosate Resistant Genome Abstracts onto the market commensurate with the expiration of their Glyphosate patents.  This allowed their domain of Glyphosate to be liability umbrella covered by the former EPA guidance on the herbicide/toxicant/biocide, while the open domain market use of Glyphosate now will be administered under the newer understandings of toxicity which have been discovered since Approval by the EPA.  In this way, Monsanto dodges the liability on the negative health effects of Glyphosate, endures the ramp up period for the growth of business from a gateway patent, and secures ultimate risk-free profitability through a complimentary and solely dependent technology: Glyphosate resistance through patented GM seed.

A brilliantly executed strategy.

Toxicology Studies Executed AFTER FDA Approval and Glyphosate Enabling GMO Maps were Abstracted by Monsanto

Please note that after the EPA approval in 1991, despite the prodigious amount of new contra indicative data since on HUMANS and higher order mammals, Monsanto ceased critical safety-oriented clinical studies of Glyphosate altogether. They left it to the rest of the world to perform lifecycle and safety-diligence science through a nascent sufficient level of observational and intelligence base of data.  Knowing that these opponents would have a ‘King of the Hill’ battle against bureaucracy, collusion, corruption and false skeptics, Monsanto strategically planned to sit back and do nothing thereafter. Notice that not even one study since, has been completed by Monsanto or their shill third party labs which underpinned the 1991 EPA approval effort.

Mark Twain2015     Journal of Environmental Health, Environmental Health Aug 25 2015, 14:70  doi:10.1186/s12940-015-0056-1Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure.

2014     Journal of Seed Science, Print version ISSN 2317-1537; J. Seed Sci. vol.36 no.1 Londrina  2014 http://dx.doi.org/10.1590/S2317-15372014000100008  Yield and quality of wheat seeds as a function of desiccation stages and herbicides.

2006     Tomlin, C. D. S. The Pesticide Manual: A World Compendium, 14th ed.; British Crop Protection Council: Hampshire, UK, 2006; pp 545- 548.

1998     Roberts, T. R. Metabolic Pathways of Agrochemicals-Part 1: Herbicides and Plant Growth Regulators; The Royal Society of Chemistry: Cambridge, UK, 1998; pp 396-399.

2002     Herbicide Handbook, 8th ed.; Vencill, W. K. Ed.; Weed Science Society of America: Lawrence, KS, 2002; p 231-234.

mortality-300 - Copy2000     Giesey, J. P.; Dobson, S.; Solomon, K. R. Ecotoxicological risk assessment for Roundup herbicide. Rev. Environ. Contam. Toxicol. 2000, 167, 35-120.

2010     SRC PhysProp Database: Glyphosate; Syracuse Research Corporation. http://www.syrres.com/what-we-do/databaseforms.aspx?id=386 (accessed Dec 2007), updated Jan 2010.

2000     Shaner, D. L. The impact of glyphosate-tolerant crops on the use of other herbicides and on resistance management. Pest Manag. Sci. 2000, 56, 320-326.

1991     Franz, J. E.; Mao, M. K.; Sikorski, J. A. Glyphosate: A Unique Global Herbicide; American Chemical Society: Washington, DC, 1997; pp 521-527, 604-605, 615.

1996     WHO. Data Sheets on Pesticides: Glyphosate; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Geneva, Switzerland, 1996.

2006     Wu, J. Y.; Chang, S. S.; Tseng, C. P.; Deng, J. F.; Lee, C. C. Parenteral glyphosate-surfactant herbicide intoxication. Am. J. Emerg. Med. 2006, 24 (4), 504-506.

2000     Williams, G. M.; Kroes, R.; Munro, I. C. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 2000, 31, 117-165.

2004     Bradberry, S. M.; Proudfoot, A. T.; Vale, J. A. Glyphosate poisoning. Toxicol. Rev. 2004, 23 (3), 159-167.

2000     Bates, N.; Campbell, A. Handbook of Poisoning in Dogs and Cats – Glyphosate; Campbell, A.; Chapman, M., Eds.; Blackwell Science Ltd: Oxford, England, 2000; pp 135-138.

1998     Monsanto Department of Medical and Health Sciences. Roundup and other gyphosate/tallowamine surfactant-containing herbicides: The clinical effects and their managment. Unpublished report, 1994, cited in Burgat, V.; Keck, G.; Guerre, P.; Bigorre, V.; Pineau, X. Glyphosate toxicosis in domestic animals: A survey from the data of the Centre National d’Informations Toxicologiques Veterinaires (CNITV). Vet. Hum.Toxicol. 1998, 40 (6), 363-367.

2004     Rattray, N. J. Glyphosate acid: 4-hour acute inhalation toxicity study in rats. Unpublished Report no. CTL/P/4882, study no. HR2884, 1996, submitted to WHO by Syngenta Crop Protection AG, Basel, Switzerland, prepared by Zeneca Agrochemicals, Central Toxicology Laboratory, Alderley Park, Maccelsfield, Cheshire, England. Pesticide Residues in Food – 2004: Toxicological evaluations; International Programme on Chemical Safety, World Health Organization: Geneva, Switzerland, 1996.

2004     Welch, S. Glyphosate. Clinical Veterinary Toxicology; Plumlee, K. H., Ed.; Mosby: St. Louis, 2004; pp 162-163.

1998     Burgat, V.; Keck, G.; Guerre, P.; Bigorre, V.; Pineau, X. Glyphosate toxicosis in domestic animals: A survey from the data of the Centre National d’Informations Toxicologiques Veterinaires (CNITV). Vet. Hum. Toxicol. 1998, 40 (6), 363-367.

1999     Acquavella, J. F.; Weber, J. A.; Cullen, M. R.; Cruz, O. A.; Martens, M. A.; Holden, L. R.; Riordan, S.; Thompson, M.; Farmer, D. Human ocular effects from self-reported exposures to Roundup herbicides. Hum. Exp. Toxicol. 1999, 18 (8), 479-486.

2009     Glyphosate. Human-Health Assessment Scoping Document in Support of Registration Review; U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC, 2009.

2004     Acquavella, J. F.; Alexander, B. H.; Mandel, J. S.; Gustin, C.; Baker, B.; Chapman, P.; Bleeke, M. Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study. Environ. Health Perspect. 2004, 112 (3), 321-326.

2007     Cavas, T.; Konen, S. Detection of cytogenic and DNA damage in peripheral erythrocytes of goldfish (Carassius auratus) exposed to a glyphosate formulation using the micronucleus test and the comet assay. Mutagenesis 2007, 22 (4), 263-268.

bladder cancer incidence2004     FAO. Pesticide Residues in Food – Evaluations Part 2: Toxicological; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Rome, Italy, 2004.

2005     De Roos, A. J.; Blair, A.; Rusiecki, J. A.; Hoppin, J. A.; Svec, M.; Dosemeci, M.; Sandler, D. P.; Alavanja, M. C. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ. Health Perspect. 2005, 113 (1), 49-54.

2004     Moxon, M. E. Glophosate acid: multigeneration reproduction toxicity in rats. Unpublished report no. CTL/P/6332, study no. RR0784, 2000, submitted to WHO by Syngenta Crop Protection AG, Basel, Switzerland, prepared by Zeneca Agrochemicals, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, England. Pesticide Residues in Food – Evaluations Part 2: Toxicological; International Programme on Chemical Safety, World Health Organization, Food and Agriculture Organization: Rome, Italy, 2004.

2003     Hori, Y.; Fujisawa, M.; Shimada, K.; Hirose, Y. Determination of the herbicide glyphosate and its metabolite in biological specimens by gas chromatography-mass spectrometry. A case of poisoning by roundup herbicide. J. Anal. Toxicol. 2003, 27 (3), 162-166.

2002     Aprea, C.; Colosio, C.; Mammone, T.; Minoia, C.; Maroni, M. Biological monitoring of pesticide exposure: a review of analytical methods. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 769 (2), 191-219.

2008     Motojyuku, M.; Saito, T.; Akieda, K.; Otsuka, H.; Yamamoto, I.; Inokuchi, S. Determination of glyphosate, glyphosate metabolites, and glufosinate in human serum by gas chromatography-mass spectometry. J. Chromatogr. B 2008, 875, 509-514.

2004     Biagini, R. E.; Smith, J. P.; Sammons, D. L.; MacKenzie, B. A.; Striley, C. A.; Robertson, S. K.; Snawder, J. E. Development of a sensitivity enhanced multiplexed fluorescence covalent microbead immunosorbent assay (FCMIA) for the measurement of glyphosate, atrazine and metolachlor mercapturate in water and urine. Anal. Bioanal. Chem. 2004, 379 (3), 368-374.

2007     Curwin, B. D.; Hein, M. J.; Sanderson, W. T.; Striley, C.; Heederik, D.; Kromhout, H.; Reynolds, S. J.; Alavanja, M. C. Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in iowa. Ann. Occup. Hyg. 2007, 51 (1), 53-65.

2008     Tsui, M. T. 60. K.; Chu, L. M. Environmental fate and non-target impact of glyphosate-based herbicide (Roundup) in a subtropical wetland. Chemosphere 2008, 71, 439-446.

2005     Curwin, B. D.; Hein, M. J.; Sanderson, W. T.; Nishioka, M. G.; Reynolds, S. J.; Ward, E. M.; Alavanja, M. C. Pesticide contamination inside farm and nonfarm homes. J. Occup. Environ. Hyg. 2005, 2 (7), 357-67.

2004     Howe, C. M.; Berrill, M.; Pauli, B. D.; Helbing, C. C.; Werry, K.; Veldhoen, N., Toxicity of glyphosate-based pesticides to four North American frog species. Environ. Toxicol. Chem. 2004, 23 (8), 1928-1938.

4.  There exists a pronounced rise in diseases associated with the original toxicity issues evaluated in the EPA Approval; specifically pancreatic, endocrine and skin inflammation disorders
OCKHAM’S RAZOR PLURALITY HAS BEEN DRAMATICALLY SURPASSED: There Exists a Problem with Our Food – And No, Exercising More Will Not Fix This

diabetes and glphsateCompare the chart at the right with the Glyphosate employment curve shown above; and remember that by 2008, Glyphosate tolerant crops constitute 85 – 90% of the food bio-availability in their respective use classes. I am not sure that we can wait to finally find out what it is we must to do to convince the oppressive Social Skepticism movement to step aside and allow real actual science to proceed. To continue to actively ignore this set of maladies, endocrine, inflammation and auto-immune in nature, is the height of malicious incompetence.  And remember, one principal goal of the Social Skepticism cabal is the Cultivation of Ignorance, the false premise that you must bring final and conclusive proof at the beginning of the scientific method; along with the commensurate manipulation of the conscience of science to support oligarch cronies. This constituting just one technique inside the variety of ways to cultivate ignorance through manipulation of the scientific method. The graphic to the right is posted, courtesy of Farm Wars (http://farmwars.info/?p=11543) and demonstrates the dramatic growth in diabetes incident upon the US population underway. No, this is not simply because the population is aging. Our children are inheriting these diseases on a regular basis now. To presume that you know the impetus behind this alarming statistic, as a means to squelch study, not stimulate it – is pseudoscience. The advocate producing this comparative on the right, indexing the coincidence between GM Food technologies and the rate of increase in diabetes, is petitioning for research – not providing excuse to block research – so he or she is actually conducting work in accordance with the scientific method.

But the bad news is that diabetes apparently is a 2 year lag sensitive malady induced from environmental factors, apparently factors which appeared in the American diet around 1995. But cancer on the other hand is more of a 15 to 40 year lag statistic as we have seen from smoking data and its impacts on stomach, bladder, esophageal and lung cancer data. Accordingly we should see a curve building now, stemming from the 1995 introduction of the first broad scale glyphosate resistant crops in 1995. Indeed, when we examine pancreatic cancer, we see exactly what might be expected; in fact, a terrifying picture.

Pancreatic Cancer Increase GraphNot only are we experiencing a pandemic rate of diabetes, but pancreatic cancer, once rare, has now skyrocketed to become the fourth leading cause of cancer death in the United States. The United States not only leads the world in rates of diabetes, but in rates and deaths of pancreatic cancer as well. We cannot continue to blame these observations on super sized meals, in absence of having really conducted any research. A counter claim cannot be tendered in a pluralistic argument, without evidence. According to the National Cancer Institute, in 2014, over 46,400 people will be diagnosed with pancreatic cancer – this is up 114% since the 2012 GLOBOCAN North American measured rate, which was already 18% higher than the rest of the planet on average. ¹ ³

US Pancreatic Cancer Case Incidence 2012   21,713
US Pancreatic Cancer Case Incidence 2014   46,400
 
N American Avg Pancreatic Cancer Incidence   2.6%
World Avg Pancreatic Cancer Incidence   2.2% 

And no, arch cynic Steven Novella cannot blame these stats on ‘an increase in focus on and diagnosis of’ since 80+% of these victims die of this cancer and usually in about a little over a year on average. A study leader Dr. Peter Storz, a cancer biologist at the Mayo Clinic in Jacksonville, FL, who – with colleagues – describes their findings in the journal Cancer Discovery, says: ²

Our study shows a “direct link between Kras mutations and the inflammatory environment that drive the initiation of pancreatic cancer.”

It is clear from the post 1991 evidence and studies cited in section 3 above, that pancreatic inflammatory impacts were a principal observed element inside the observed set of effects of glyphosate on higher order mammals. The criminal stupidity displayed on the part of our arch SSkeptics, seeks to BLOCK, yes BLOCK the science which could prove matters such as the impact of this food additive, glyphosate, on our public health.

5.  Glyphosate is not optional. You can’t wash Glyphosate off, and it is contained in 90% of the bio-available foods of each major US Consumer Food category.

rosacea obesity and endocrine collapseOne cannot avoid Glyphosate except through an enormous amount of diligent research and through a highly restrictive diet. The products do not inform their victims of the incumbent potential dangers documented since 1991. Rosacea, Obesity from Endocrine Collapse and the requisite Auto-Immune Disruption, are all a concern among Americans today. I was able to alleviate these symptoms by elimination of Glyphosate related foods. Elimination of corn, wheat, soy, canola dairy and alfalfa is not an accomplishment which the vast majority of Americans can achieve.  The foods are not labelled such that they can, even if they wanted. Resource sites provided by the American Autoimmune Related Diseases Association, for persons truly interested In or suffering from Endocrine, Rheumatoid or Autoimmune Diseases:

http://www.aarda.org/Basic_Autoimmunity.swf

http://www.aarda.org/Rheumatic_Autoimmune_Disease.swf

IBS versus supplements harm - Copy - Copy - CopyRelated original studies which cited that pancreatic, endocrine, skin and inflammation disorders were an issue

Arbuckle, T. E.; Lin, Z.; Mery, L. S. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environ. Health Perspect. 2001, 109 (8), 851-7.

Maibach, H. I. Irritation, sensitization, photoirritation and photosensitization assays with a glyphosate herbicide. Contact Derm. 1986, 15, 152-156.

Talbot, A. R.; Shiaw, M. H.; Huang, J. S.; Yang, S. F.; Goo, T. S.; Wang, S. H.; Chen, C. L.; Sanford, T. R. Acute poisoning with a glyphosatesurfactant herbicide (‘Roundup’): A review of 93 cases. Hum. Exp. Toxicol. 1991, 10 (1), 1-8.

McConnel, R. A chronic feeding study of glyphosate (Roundup technical) in mice: pathology report on additional kidney sections. Unpublished project no. 77-2061A, 1985.

Stout, L.; Ruecker, F. Chronic study of glyphosate administered in feed to albino rats. Unpublished Report no. MSL-10495 R.D. 1014, 1990.

Lavy, T. L. Conifer seedling nursery worker exposure to glyphosate. Arch. Environ. Contam. Toxicol. 1992, 22, 6-13.

Jauhiainen, A.; Rasanen, K.; Sarantila, R.; Nuutinen, J.; Kangas, J. Occupational exposure of forest workers to glyphosate during brush saw spraying work. Am. Ind. Hyg. Assoc. J. 1991, 52 (2), 61-64.

Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology. 2013;6(4):159-184. doi:10.2478/intox-2013-0026.

6.  The Public is asking that the science be completed/updated. They would like to be informed so they can make choices. This is their right.

A profile in sufferingSignificant portions of the scientifically and medically minded, as well as the professional population of our country are standing up and raising concerns over what they are observing in their children. No, the rise in obesity, diabetes, thyroid disease and other maladies cannot be explained by calories and exercise. No, you cannot dissuade ethical questions by charades of ‘critical’ or ‘skeptical’ thinking.

“Nearly one quarter, 25 percent of all Americans ages 17-24 are too overweight to serve. Obesity is not only affecting those who can qualify for military service, it is also creating challenges for our active duty military,” Tomaszeski said.

   – U.S. Navy Rear Admiral Steven Tomaszeski, CBS Baltimore, ‘Obesity Affects Number Of Those Eligible For  Military Service;’ Nov 20, 2014.

Yes, there is a growing fire. The fire is the observed inflammation in our bodies, skyrocketing since 1995, along with the incumbent increase in Endocrine-Immune Disruption. Rome is burning.  It is our national health, security and prosperity. All placed in danger while we fiddle with a

  • 1.2% increase in the crop price (6 cents a bushel net on sale),
  • 7.5% increase in yield and
  • savings of 2 cents a bushel on cost of production.†

As many others have expressed, let me offer up a resounding ‘yawn’ to this level of productivity and yield gain.   Post harvest perishment rates, especially in famine stricken areas of the globe are well in excess of 40%.  I work supporting nine of these nations, and trust me, yield is not the issue they face. Post harvest perishment is where the danger of famine resides, not in theoretical hectare ‘yields.’

I attended a symphony with an oncologist and her husband recently and the subject of autoimmune disease and diet came up.  She was a cancer survivor herself at age 29! This is what she related to me:

“I could never say this on the record in my profession, but the incident of previously rare cancers no longer being that rare, along with a rise in the ‘old age’ associated cancers occurring in those my age, is dramatic.  Whatever it is has occurred in the last 12 years because the stats are skyrocketing. It is obviously something environmental, but further, I think it is diet related.”

  ~ 29 Year Old Breast Cancer Survivor and Oncologist

The Michael Shermer’s of the world think that your suffering, your food sensitivities, your intestinal dysfunction, facial sores, cancers, anxiety, IBS, and endocrine maladies – ARE ALL A FICTIONAL COMEDY – they mock you in your suffering.

michael shermers of the world think your suffering is fictional comedyWe cannot continue to sacrifice our bodies for this fairy tale of how famine works – along with Social Skeptic cluelessness and arrogance concerning the suffering of everyday people. This yield and productivity result is solely intended to be employed in predatory market dynamics, masquerading as a dilettante understanding of famine mercy. Parallel to much of American economics, we are using predatory pricing, efficiencies and sourcing cartels (seed sourcing in this case, emulating China) in order to put small and medium sized competitors out of business, to the benefit of social oligopolies. These tactics are NOT mechanisms of capital economies, rather socialist economies. The measurable rise of royalty and elite elicits indication as to what is occurring in our agri-foods industry.  Socialism always bears a royalty class, hidden or visible.

Now it is up to activists like me, who were able to improve their health and reverse these diseases by eliminating specific foods (wheat, dairy, corn, canola oil, soy, cottonseed oil, alfalfa), who must petition scientists we work with and know, to start considering the idea that we must begin to conduct science on the safety and health impacts of the food we are consuming. Believe it or not, science that has been obstructed by the very organization who’s job it should have been to protect us in the first place.

Plurality has been established on this issue:  Our food is in question – Glyphosate is in question – We must begin the actual third party, skeptical science.


¹  GLOBOCAN Worldwide Estimated Cancer Incidence 2012, sorted by cancer site; North America/United States/Pancreatic Cancer; http://globocan.iarc.fr/Pages/fact_sheets_population.aspx

²  Researchers identify first molecular steps that lead to pancreatic cancer; Last updated: 10 November 2014 at 3am PST; Medical News Today, http://www.medicalnewstoday.com/articles/285173.php?linkId=10916036

³  National Cancer Institute, Pancreatic Cancer Summary; http://www.cancer.gov/cancertopics/types/pancreatic

†  Hybrid Wheat, Cisar/Cooper, FAO Document Repository, http://www.fao.org/docrep/006/Y4011E/y4011e0c.htm

‡  ABCD Seed Cartel: Archer Daniels Midland Company, Bunge, Cargill , Louis Dreyfus Group.