The Ethical Skeptic

Challenging Pseudo-Skepticism, Institutional Propaganda and Cultivated Ignorance

Ketosis Lab Notes – Mitochondrial Suppression Disorder

Some people merely need cut out desserts for a month in order to lose the weight their doctor recommends. Others can consume and burn that same amount recommended by their doctor and still gain a substantial amount of weight throughout the course of each year. This despite matching their lower weight peers food for food, activity for activity. This latter condition is what is known as mitochondrial suppression.
Until the mitochondrial suppression sufferer can get into a therapeutic daily state of endogenous (and not exogenous) ketosis, they will continue gain more weight over time, and suffer more diseases of chronic malnutrition, than do their comparable practice non-sufferer peers. A keto diet is not a diet ‘high in fats’, rather it is a diet which cuts out the noise which carbohydrates add, so that one can perform diagnostics to determine the level of mitochondrial suppression from which they suffer.

Have you ever had a friend or an advising physician who seemed to be able to keep the weight off simply by cutting out desserts or initiating a little bit of exercise every once in a while? Have you experienced the challenge of exercising every single day, and constricting calories until you suffer severe malnutrition and the associated chronic diseases, for decades – yet you are still statistically ‘obese’? Well, there is a reason for this apparent inequity. Most Americans who do not suffer from this inequity, have no idea the extents to which its sufferer must go, in order to maintain a trim appearance and remain physically healthy. What is contained inside this blog article is not a study – rather a disciplined set of observation to intelligence to necessity. It stands as an appeal for plurality under Ockham’s Razor, concerning this very real physiological condition which I call: mitochondrial suppression. The efforts you will observe in this article constitute the obfuscated start of our scientific method, which labors truncated, beneath the overweight burden of our elitist, apathetic and fake form of skepticism. Herein we actually go there, look, experience, live for years inside, record observations, conduct analysis of, and develop a dissenting intelligence regarding an issue which they and their cronies have had all figured out through mere armchair plausibility.1

I have established in my own metabolism, a 650 calorie per day, every single day of my life, disadvantage. I must exercise more and eat less, than the average person to recover this imbued deficit, or face inevitable obesity – not overweight – obesity. Obesity is the disease which results from the environmental factor which is causing this mitochondrial suppression in Americans.

This entire cycle has nothing whatsoever to do with overeating and lack of exercise. You will observe social skeptics who get angry over keto diets and ketone tracking, because this analytical approach to weight management arms Americans with information2 – information they need in order to run diagnostics and observe mitochondrial suppression in their own bodies. Social skepticism thrives on, and maintains a goal of, ignorance. You will note that social skeptics grow angry any time their preferred state of ignorance is threatened.

“As early as 1969, research showed that losing just 3 percent of your body weight resulted in a 17 percent slowdown in your metabolism—a body-wide starvation response that blasts you with hunger hormones and drops your internal temperature until you rise back to your highest weight. Keeping weight off means fighting your body’s energy-regulation system and battling hunger all day, every day, for the rest of your life.”

     ~ Michael Hobbs, “Everything You Know About Obesity is Wrong”; Huffington Post3

Below I have run a series of tests in incremental critical path progression, and shown the associated bench notes upon a test subject’s4 physiology and blood chemistry, as it pertains to ketosis and the key energy centers inside the human cell, the mitochondria. I have identified an issue with regard to normal caloric consumption inside a particular human body physiology: that of the mitochondrial suppression sufferer.

There exist two states of human caloric burn profile, the normal function modeled by the orange curve in the Exhibit above, and the mitochondrial suppression curve modeled from the below observation data, in blue. While the below observation appeal does not pretend to suggest a cause for this malady, let’s take a look for a moment at an article which does. The below Time Magazine article suggests that much of medical science today not only understands that this condition exists; but moreover, after decades of enforced false moralizing wisdom, is finally in pursuit of its root, and fairly recent, cause.

What the researchers believe could be responsible for these differences [in metabolic profiles] is the microbiome—trillions of bacteria that live in the gut and differ wildly from person to person. Another recent study published in the journal Obesity Research & Clinical Practice found that even if they exercised and ate the same amount, an adult in 2006 is heavier than one in 1988. The study authors also suggested that changes in the microbiome could be at play, amid other possibilities. ~Alexandra Sifferlin, Time Magazine: “Why Losing Weight Is So Hard for Some People”5

The Normal Mitochondrial Burn

In the normal mitochondrial burn human physiology, a typical active person can consume on the order of 3000 calories per day, achieve the necessary USRDA 100% critical 90 human nutrients, and still initiate a condition called endogenous ketosis, wherein the body uses up its stores of glycogen, and begins to burn off a bit of body fat each day. In this type of body mitochondrial energy profile, if one gains a bit of weight over the years, generally all one has to do is cut out desserts or another favorite indulgence for a month, or exercise a bit – and things will be fine in a matter of weeks.  This is the type of person a typical doctor thinks they are encountering with every single new patient. I mean, it works for them right? Then why would it not work for everyone? Of course it works for everyone. Formula, rote, easy – the essence of abductive inference and diagnostician’s error. This type of physiology (orange curve above) generates a mitochondria-to-energy supply environment which produces a steady stream of ketone based cerebral and physical energy throughout most of the day. This type of endogenous keto-energy is clean and not brain-fog inducing. A tremendous resource which makes addressing the challenges of school and work, a bit less daunting. One would find it very difficult to attain a PhD, or much less become a doctor, were this beneficial physiology not in play. This, to my understanding, is why we have few doctors who know how to treat or have faced themselves, mitochondrial suppression.

My buddy from the Navy is like this. After 5 years, with no exercise regimen to speak of, he found he had gained 5 pounds since he left college. His pants were getting a bit tight. He cut out moose tracks ice cream for a month and everything was fine. He spent his extra time not exercising, by studying for his MCAT and medical school. He did well. ‘Why can’t everyone do this?” he would ask.

The condition cited in the case of my buddy above, is called ‘being overweight’ – this condition has nothing whatsoever to do, statistically, causally nor epidemiologically, with the condition of being obese. Most of our doctors today do not realize this, because they have been disinformed on this subject – both by their advisory resources and by their own life experience. Not everyone is like my friend above, especially when it comes to mitochondrial activity and a body’s ability to sustain an endogenous ketosis state on a daily basis.

The Suppressed Mitochondrial Burn

Those suffering mitochondrial suppression and the incumbent lack of nutrition and mental alacrity, who do manage to complete advanced degrees, work achievements or become doctors, are persons of extraordinary fortitude, persistence and character. They suffer through every single day of their lives – abjectly unaware that this level of suffering is anything but normal.

Fully unable to benefit from the pure mental energy derived from the ketone flush, they instead rely upon carbohydrates, alcohol, sugars and coffee to feed their cognitive endurance, and power through the challenge of each new day by means of utter survival. Their bodies bearing testament to the incumbent malady – mitochondrial suppression.

In the physiology exhibiting mitochondrial suppression (the blue curve in the Exhibit above), the sufferer is unable to consume a sufficient level of food which imparts the USRDA 100% for the majority of the 90 critical human nutrients, without greatly exceeding his or her caloric burn curve. By a good 650 calories per day. Exacerbate this condition through the most recent two-decade dilution of nutrient versus caloric biomass in our new growth-accelerant based agricultural products, and you have a stark and challenging epidemic at hand. In other words, if the mitochondrial suppression sufferer, despite a normal diet and exercise lifestyle, were to eat enough food in order to avoid the chronic diseases related to malnutrition, they would gain on the order of 30 lbs per year. Comparatively, the normal mitochondrial burn physiology person would remain at the same weight, and obtain all the nutrient they need.

The bottom line is that the person, like our test subject, who exhibits mitochondrial suppression, must undertake physical exercise above and beyond a normal active day burn curve, to the order of 650 calories per day – in order to consume enough food to ward off chronic diseases of malnutrition.

The old adage that ‘You get all the nutrition you need in a typical Western Diet’ – is a load of baloney for those who suffer mitochondrial suppression. Below, you will find my bench notes, developed from my study of the subject over the last 8 months. It took me some time and diligent measuring, to begin to observe what was going on (in the scientific method, this is called observation, intelligence and necessity – the part fake skeptics leave out). Once I had my observations, thoughts, measures and critical line of questioning/testing/reasoning gathered, I digested them into the set of bench notes depicted below.

A side discovery gleaned from the bench notes: Exogenous (provoked) ketosis is not the same condition as is endogenous ketosis. Exogenous ketone or BHB salts6 are a way to stimulate the body to produce a blood chemistry very similar to that found during endogenous (natural internal) ketosis. However, exogenous ketone salts and exogenously provoked ketosis, do not stimulate the body out of mitochondrial suppression to the same degree as does endogenous ketosis. Therefore the only effective therapeutic use of ketosis, is to create it naturally in the body. I was very disappointed as I deduced this answer, but this appears to be a sound principle (see bench notes below).

Round Up the Usual Suspects

Before we examine actual evidence however, let’s conduct a Google search to observe the current common wisdom surrounding this topic. I took a sweep through Google to see the top 40 sites which comment upon certain peoples’ inability to lose weight, and here is what they said in summary. The first two reasons are mutually exclusive, but cover all the options through a guaranteed-to-send-you-reeling bifurcation. Pseudo-theory spun inside the very first quips I encountered. The deceptive nature of pseudo-theory hinges upon the critical principles that – it comprehensively addresses every condition of plausibility, explains everything, and tenders conjecture inside realms of victim blame, or where testing is not easily conducted. Fortunately, there are people like me who do test these axioms. The advice below has consistently failed Americans for decades, and upon disciplined scrutiny, consistently turns out to be false.

   The Bullshit Blame of the ‘You Are’s’

  1. You are lying and you eat more than you say you are.
  2. You are not eating enough, your body is in ‘starvation mode’.
  3. You are mistaken that extra physical activity or exercise will cause you to lose weight.
  4. You are eating the wrong foods (what are these? what you are eating of course!) or the same foods all the time.
  5. You are doing the same exercise, or too much cardio, or are lifting weights too much or not enough.
  6. You are not getting enough sleep or are sleeping too long.
  7. You are drinking soft drinks or too much alcohol.
  8. You are too stressed out.
  9. You are gluttonous and lazy – and your memory of this is flawed – because memory is an unreliable form of evidence.
  10. You are ‘dieting’ and need a ‘lifestyle change’ – usually involving 6 am workouts and consuming 1200 calories per day and buying lots of high cost products and magazines.

Boy, they pretty much nailed 100% of the US demographic with these pearls of wisdom. Well done. Based upon this set of infallibles, everyone should be obese. The principle contained in this plethora of bullshit paid-pseudo-advice (pseudo-theory, which inhabits 38 of the top 40 rankings in a Google search7) doubles down upon the agenda of accusing the mitochondrial suppression victim of being the cause of the problem themself. Do we smell corporate social skepticism at play here? These old worn fables bear the very exploitation of journalism, plural arguing and Art of The Professional Lie characteristics which are the core habits of the social skepticism cabal. The straightforward critical path is, as a grouping, everyone does the things above. And among everyone, there exist some who are obese, some who are overweight, and some who find it hard to put on weight at all. So another differential factor is at play, undercurrent to this group of ignoratio elenchi disinformatives.

Fortunately for purposes of this eight month study, the test subject had already addressed all these pop-science factors. They were not effective in the least at contributing to weight loss. As well, please note with caution that a 1200 calorie a day Hollywood Starlet diet for the rest of your life, will make you chronically sick for the rest of your life – or even kill you. Do not do this. In order to obtain enough nutrient and to avoid chronic disease, you will need to consume 1800-2400 calories per day and supplement with 90 nutrients, and initiate a therapeutic endogenous ketosis each and every day (see below).

Ketosis, and the inability to enter that state, is the key problem. This is an issue of environmental compromise of body systems – and NOT human personal habits, within reason. If you are gluttonous and lazy, this is not the relevant domain nor context of our argument here. This serves to point out two rules about social skepticism, from the pages of The Tree of Knowledge Obfuscation.

Google Blame Ranking Effect – If advice about what you are personally doing wrong, inhabits 90% of the first three pages of ranked responses on Google, it is most certainly wrong.

culpant et victima – Whenever a culprit is being concealed as to their introduction of a deleterious contribution, the victims will be assigned the blame for their handiwork.

So, without further ado, let us get back to the primary subject of this blog. The test subject initiated an 8 month protocol of ketosis testing, tracking and charting blood chemistry, detailed caloric consumption, life factors, exercise and weight, each day. Detailed charts were maintained and compiled into a series of bench notes below. A sample daily diary entry is shown in the chart immediately below. What follows hereafter are the results.

The Key Finding: Mitochondrial Suppression

The key finding of the 8 month effort was as follows.

A subset of normal health Americans are unable to lose weight at the medically established, and otherwise commonly attained, rate of 1 pound per 3500 calories of shortfall between physical activity burn and dietary consumption.8 It is conjectured that the experiencer of this disadvantage in physiology is suffering from a specific underlying condition which prohibits their ability to attain this normal physiological energy to meta-weight profile. This test, and the body of other studies like it, demonstrate that the sufferer of this conjectured disadvantage condition will also coincidentally experience difficulty in establishing daily therapeutic inception of natural endogenous ketosis. It is further conjectured that these two phenomena are causally linked, and as a factor set, far outweigh the impact of all other factors in terms of contribution to the sufferer’s healthy weight and weight loss. Therefore, it is conjectured that there exists a phenomenon of unknown cause among some of the American population, wherein a suppression of endogenous ketosis, as a reaction of the body’s cell-energy mitochondria management, is indicated.

Same individual, same lifestyle habits – two different seven day periods of 14,000 calorie shortfall between physical activity and food consumption.9 During the first test week (Exhibit A) the individual did not attempt any ketosis stimulation (shown in list below) and did not subsequently enter endogenous ketosis of any significance for the 7 day period – herein a weight loss of 1 lb was experienced. During an earlier week however (Exhibit B), the same profiled 14,000 calorie shortfall and practice set produced a 4.5 lb weight loss. However this week (Exhibit B) featured an average 35 mmol/L-hour sustained ketosis profile each day of that period. This same circumstance was replicated 3 more times. The weeks were separated in time so as not to be adjacent and influenced by weight measures shifting from one week to the next.  As a benchmark, the individual should have lost 3 to 4 pounds under normal expectation, even during the weeks which did not feature a ketosis mmol/L signature (as typified by Exhibit A). Yet consistently the individual failed to lose weight at this rate during the weeks in which endo-ketosis did not emerge. However, consistently during the weeks in which an endogenous ketosis profile was achieved (as typified by Exhibit B), the individual actually slightly outpaced the anticipated 3 to 4 lbs of weight lost under a 14,000 calorie shortfall for the period under consideration.

It is conjectured therefore that, in some Americans, there exists a phenomenon of mitochondrial energy consumption suppression, which prevents those individuals who suffer the condition, from entering a normal physiology of body energy-to-mass management – and results in chronic, apparent-stubborn and unhealthy weight gain in an otherwise healthy and reasonably lifestyled individual. Finally, it is conjectured that these same individuals, by means of the same underlying physiological contributor which expresses as mitochondrial suppression and/or through undertaking extreme measures to mitigate weight gain, may experience higher rates of chronic disease precipitated through persistent shortfalls in daily nutrition.

Stimulating Endogenous Ketosis

Stimulating endogenous (not provoking exogenous) ketosis is the only way to sustain weight loss in the mitochondrial suppression physiology. In the chart to the right you may observe that endogenous ketosis comes in the late morning or early afternoon, only after making the required disciplines (listed below). Once endo-ketosis is established, a limited amount of calories may be eaten. In the chart to the right you will see the impact of this caloric intake (yellow arrows) upon the overall state of endo-ketosis. The diary entry to the right constitutes a 70 mmol/L-hr day. Under this sustained profile, a person with mitochondrial suppression would lose 2 – 4 lbs per week. In absence of this ketosis curve, a person with mitochondrial suppression might lose nothing at all or very little, despite featuring the same caloric intake and activity profile. Taking BHB Salts will not produce this necessary endogenous condition the mitochondrial suppression sufferer needs – constituting merely an emulation of the same or similar blood profile acetoacetic acid mmol/L (millimoles per litre).  Below I have listed some tactics the test subject employed successfully to create ketosis (shown in the graphic to the right) on a regular basis (measured in the bench notes as mmol/L-hr, or millimoles per litre-hours – or “Volume’), under the period of this study.

   Tactics of Successful Endogenous Ketosis Under Mitochondrial Suppression

1.  Keep carbohydrate and sugar consumption low in the latter part of the day, after 6pm. Keep carb and sugar consumption low as an overall intake profile.

2.  Avoid consumption of food after 8pm each day. This benefits in ketosis the next day.

3.  Drink coffee in the AM and early PM, with 1/2 oz of MCT oil. This encourages the brain to release the body from the mitochondrial suppression state.

4.  Exercise is a must. Every day. Exercise does not immediately induce endogenous ketosis on the day it is performed, but it contributes to the next day’s endo-ketosis level.

5.  Psyllium husk added to the diet later in the day, will assist in attaining ketosis the next day, by helping keep the colon clean of debris. You will find that the ability to enter endo-ketosis and the state of the colon, are intimately linked. This will stand as a hint as to the cause of mitochondrial suppression later on.

6.  Bio-Available forms of vitamins B1, B2, B5, B6, NADH (B3), methylfolate (important: do not take ‘folic acid’) and methylcobalamine (B12) – all these MUST be taken early every morning and in the evening as well on hard activity days. The body will not kick off its Kreb’s Energy Cycle (and the resulting endo-ketosis) in absence of these critical nutrients. If you delay the intake of these vitamins, you will delay the onset of endogenous ketosis each day and reduce the resulting mmol/L-hrs you benefit from.

7.  Fasting, after breakfast and through the entire day all the way to a vegetable and protein 8pm dinner, is essential. If you can, fast for an even longer period, once a week. Eating steadily throughout the day only works AFTER you have established an 8 mmol/L endogenous ketosis or higher, and reasonably early in the day.

8.  Caloric intake must be well below the nutrient-sufficient 3000 calorie day (1800 – 2400 at most). Therefore you are going to NEED to supplement with critical proteins, vitamins and negative ion fulvic acid.

9.  Consume foods which match your genetic disposition and health. A good resource for this approach can be found at Dr. Peter J. D’Adamo’s site: Eat Right 4 Your Type (or book of the same name on Amazon) For me this involved cessation of wheat, barley, oats, corn, soy, canola oil, cottonseed oil, as well as pretty much anything bearing a risk of being sprayed with glyphosate (including to desiccate beans and seeds).

10.  Track your blood acetoacetic acid levels, via urine test strips, every two hours throughout the day until around 10pm. Keep track of what influences serve to therapeutically sustain endogenous ketosis day after day in your body.

11.  Ketosis can be earmarked by a very clear and alert mind – the pure energy of ketones in the blood performing much better as a cognitive energy source than either sugar or carbohydrates. However, one must eat steadily and in small quantities, once 8 mmol/L or higher has been established each day, in order to avoid keto-crash flu. Keto flu takes about 4 to 6 hours to recover from, and risks prompting the mitochondrial suppression victim to over-consume in response to its feeling of sickness/weakness.

12.  Ketosis is very hard to establish until one has taken a bowel movement. This is a sign, I conjecture, that the body is using every single calorie it can find – including ingesting ‘bad’ or contaminated calories, in order to sustain a substitute in its avoidance of using stored ketone energy.

Below, please see the notes I have assembled on this process of critical reduction.

The next question, and the one which social skeptics do not want answered, is: “What is the cause of mitochondrial suppression in its vulnerable American demographic?” It is something which kills microbiome bacteria and was introduced into our diet in the late 1990’s. Not sure what that could be. 🤔

We will get to that question in the coming years, as a group of pro-science and ethical skeptics.

Bench Notes on Mitochondrial Suppression and Ketosis

epoché vanguards gnosis

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How to MLA cite this blog post =>

The Ethical Skeptic, “Ketosis Lab Notes – Mitochondrial Suppression Disorder” The Ethical Skeptic, WordPress, 17 Aug 2018; Web, https://wp.me/p17q0e-7G5

 

  1. “An obese friend of mine commented on how well his new diet was going, as he absentmindedly devoured an entire low-carb cheesecake while happily engaged in his sedentary pastime. …There’s plenty of blame to go around for what is being called the 21st century pandemic of obesity. The western lifestyle is always the first target of blame, for good reason. Americans eat too much and exercise too little.” ~Steven Novella, Social Skeptic; http://www.theness.com/index.php/the-skeptics-diet/
  2. Yvette d’Entremont;  The Outline: The keto diet is a recipe for disaster; Sep05 2018; web, https://theoutline.com/post/6133/the-keto-diet-is-a-recipe-for-disaster?utm_source=TW&zr=p3tjlb2a&zd=1&zi=wef6hg45
  3. Michael Hobbs; Everything You Know About Obesity is Wrong; Huffington Post, 19 Sep 2018; web, https://highline.huffingtonpost.com/articles/en/everything-you-know-about-obesity-is-wrong/
  4. The test subject is me. A physically fit, broad shouldered 6 ft., 190 lb male, with a daily diet of 1800 – 2400 calories and a daily burn of 3600 – 4400 calories. The test subject, gains weight when caloric consumption rises above 2600 calories. The test subject has suffered from diseases of chronic malnutrition for over a decade, due to the need to restrict caloric intake for weight and appearance benefit. The test subject supplements with 90 vitamins, minerals and proteins as a hard-earned lesson learned from these nutrition shortfalls. Subject exercises each day, on the order of 450 – 1250 calories burned per session.
  5. Alexandra Sifferlin, Time Magazine – Health: “Why Losing Weight Is So Hard for Some People”; November 24, 2015; web, http://time.com/4125083/why-losing-weight-is-hard/
  6. Dr. Anthony Gustin, “What is Beta-Hydroxybutyrate (BHB) and What Does BHB Do?”; web, http://www.dranthonygustin.com/beta-hydroxybutyrate-bhb-bhb/
  7. Google search: ‘Why do some people find it difficult to lose weight’
  8. The Mayo Clinic: Healthy Lifestyle – Weight loss https://www.mayoclinic.org/healthy-lifestyle/weight-loss/in-depth/calories/art-20048065
  9. Please note that this is a somewhat extreme caloric shortfall, which is necessary however in producing an amplitude in weight signal which would be statistically significant, less influenced by fecal matter retainment and water retention contributors, which can serve to influence and invalidate smaller weight fluctuations

August 17, 2018 - Posted by | Ethical Skepticism |

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Ethical Skeptic, this is really good material and work. I do not understand but like half of it, but I get the gist of what to do. Don’t you find this lifestyle extraordinarily tedious? Do you sustain it for years on end, or what? Just curious, Ellen.

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