Obesity arises from toxic injury to the pancreatic alpha cells, leading to a deficiency in the peptide hormone glucagon. This shortfall impairs critical glucose-producing endocrine functions such as gluconeogenesis, glycogenolysis, and lipolysis—the natural processes that help maintain a healthy body mass.

Once this critical endocrine hormonal control is lost, no diet, fasting, or exercise plan can effectively correct the resulting obesity. Life becomes an endless cycle of fluctuating body mass index, accompanied by persistent carbohydrate cravings and crashes, as the body struggles to obtain glucose solely from the diet.